Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats

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dc.authoridKaya, Kürsat/0000-0002-6353-7791
dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidKaya, Kürsat/ABG-2848-2020
dc.authorwosidKamisli, Suat/JZT-8388-2024
dc.authorwosidKamisli, Suat/AAC-2706-2021
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidKamisli, Suat/JVN-4663-2024
dc.authorwosidKamisli, Ozden/AAA-6553-2020
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.contributor.authorKamisli, Suat
dc.contributor.authorCiftci, Osman
dc.contributor.authorKaya, Kursat
dc.contributor.authorCetin, Asli
dc.contributor.authorKamisli, Ozden
dc.contributor.authorOzcan, Cemal
dc.date.accessioned2024-08-04T20:41:10Z
dc.date.available2024-08-04T20:41:10Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, the beneficial effect of hesperidin (HP), a citrus flavonoid, on cisplatin (CP)-induced neurotoxicity was investigated. A total of 28 rats were equally divided into four groups; the first group was kept as control. In the second and third groups, CP and HP were given at the doses of 7 and 50 mg/kg/day, respectively. In the fourth group, CP and HP were given together at the same doses. The results indicated that although CP caused significant induction of lipid peroxidations and reduction in the antioxidant defense system potency in the brain and sciatic nerve, HP prevented these effects of CP. Besides, CP led to histopathological damage, mainly apoptosis, as well as electromyographical (EMG) changes in sciatic nerve. On the other hand, HP treatment reversed histopathological and EMG effects of CP. In conclusion, CP had severe dose-limiting neurotoxic effects and these effects of CP can be prevented by HP treatment. Thus, it appears that coadministration of HP with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.en_US
dc.identifier.doi10.1177/0748233713483192
dc.identifier.endpage851en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue9en_US
dc.identifier.pmid23552266en_US
dc.identifier.scopus2-s2.0-84940772214en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage841en_US
dc.identifier.urihttps://doi.org/10.1177/0748233713483192
dc.identifier.urihttps://hdl.handle.net/11616/96966
dc.identifier.volume31en_US
dc.identifier.wosWOS:000360667800009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjecthesperidinen_US
dc.subjectneurotoxic effecten_US
dc.subjectoxidative damageen_US
dc.subjectelectromyographyen_US
dc.titleHesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in ratsen_US
dc.typeArticleen_US

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