Evaluation of serum TWEAK, TRAIL, and oxidative stress markers in rosacea patients

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dc.authoridTürkmen, Dursun/0000-0001-9076-4669
dc.authoridAltunisik, Nihal/0000-0001-6844-1097
dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridUremis, Nuray/0000-0002-3958-4352
dc.authorwosidli, juqian/KII-7123-2024
dc.authorwosidTürkmen, Dursun/ABG-3801-2020
dc.authorwosidAltunisik, Nihal/ABG-8567-2020
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorDurmaz, Imge
dc.contributor.authorTurkmen, Dursun
dc.contributor.authorAltunisik, Nihal
dc.contributor.authorUremis, Nuray
dc.contributor.authorUremis, Muhammed Mehdi
dc.contributor.authorSener, Serpil
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:53:02Z
dc.date.available2024-08-04T20:53:02Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Rosacea is a chronic inflammatory skin disease of unknown pathogenesis. TWEAK and TRAIL are two cytokines thought to have a role in the pathogenesis of some inflammatory and autoimmune diseases. Aims The purpose of this study was to examine TWEAK and TRAIL serum levels and oxidative stress markers in patients with rosacea. Material and Method Forty rosacea patients and 40 sex- and age-matched healthy controls were involved in the study. Serum TWEAK and TRAIL levels were evaluated with ELISA kits. Serum total antioxidant status, total oxidant status, total thiol, native thiol, disulfide levels were evaluated, and oxidative stress index was computed. Results Serum levels of TWEAK, TRAIL, and oxidative stress markers did not differ statistically in the patients and controls. Both TWEAK and TRAIL levels in the patients were detected to be statistically higher in male than in female. Conclusion TWEAK and TRAIL may not have a systemic effect in rosacea, unlike other inflammatory diseases. More studies are needed to investigate the role of TWEAK and TRAIL in rosacea.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Inonu University [TTU-2021-2421]en_US
dc.description.sponsorshipThe study was supported by the Scientific Research Projects Coordination Unit of Inonu University with the project code TTU-2021-2421.en_US
dc.identifier.doi10.1111/jocd.15365
dc.identifier.endpage7055en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue12en_US
dc.identifier.pmid36083238en_US
dc.identifier.scopus2-s2.0-85138871564en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7050en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.15365
dc.identifier.urihttps://hdl.handle.net/11616/100915
dc.identifier.volume21en_US
dc.identifier.wosWOS:000861652900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectoxidative stressen_US
dc.subjectrosaceaen_US
dc.subjectTRAILen_US
dc.subjectTWEAKen_US
dc.titleEvaluation of serum TWEAK, TRAIL, and oxidative stress markers in rosacea patientsen_US
dc.typeArticleen_US

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