Apelin has inhibitory effect of endothelium-independent relaxation in the human internal mammary artery
| dc.contributor.author | Kacar, Emine | |
| dc.contributor.author | Burma, Oktay | |
| dc.contributor.author | Serhatlioglu, Ihsan | |
| dc.contributor.author | Ulker, Nazife | |
| dc.contributor.author | Uysal, Ayhan | |
| dc.contributor.author | Yardimci, Ahmet | |
| dc.contributor.author | Kelestimur, Haluk | |
| dc.date.accessioned | 2022-03-01T07:11:42Z | |
| dc.date.available | 2022-03-01T07:11:42Z | |
| dc.date.issued | 2019 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: Apelin has important effects on the circulatory system and heart. The main aim of this study was to investigate the effects of apelin-13 on the contraction induced by norepinephrine (NE), and the endothelium-independent relaxation induced by sodium nitroprusside (SNP) in human internal mammary artery (IMA) obtained from patients undergoing coronary artery bypass grafting (CABG) surgery. Material and Methods: IMA rings, obtained from patients undergoing CABG surgery, were suspended in isolated tissue baths containing Krebs-Henseleit solution, which were continuously gassed with 95% O2 and 5% CO2 at 37°C. Results: The IMA rings were pre-contracted with increasing concentrations of norepinephrine (NE 10-9–10-4 mol/l) and the endothelium-independent relaxation responses to sodium nitroprusside (SNP) were studied. Apelin-13 (10 μM) caused a dosedependent relaxation in NE pre-contracted IMA rings. Apelin also facilitated the endothelium-independent relaxation induced by SNP. Conclusion: According to the results, apelin facilitated the endothelium-independent relaxation and inhibited the contractile activity of IMA. These results suggest that apelin may be a physiological agent against the deterioration of vascular elasticity caused by endothelial damage especially in atherosclerotic cardiac patients and hypertensive patients. | en_US |
| dc.identifier.citation | Kacar, E., Burma, O., Serhatlioglu, I., Ulker, N., Yardimci, A., Uysal, A., & Kelestimur, H. (2021). Apelin has inhibitory effect of endothelium-independent relaxation in the human internal mammary artery . Annals of Medical Research, | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/53985 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Apelin has inhibitory effect of endothelium-independent relaxation in the human internal mammary artery | en_US |
| dc.type | Article | en_US |
