Beneficial effects of aminoguanidine on radiotherapy-induced kidney and testis injury

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidEkici, Kemal/AAF-6505-2022
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidtemelli, Oztun/ABE-6986-2020
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorEkici, K.
dc.contributor.authorTemelli, O.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorSamdanci, E.
dc.contributor.authorPolat, A.
dc.contributor.authorBeytur, A.
dc.contributor.authorTanbek, K.
dc.date.accessioned2024-08-04T20:42:31Z
dc.date.available2024-08-04T20:42:31Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis experimental study was designed to investigate both protective and therapeutic effects of aminoguanidine (AG), on radiotherapy (RT)-induced oxidative stress in kidney and testis. Forty rats were divided into five groups equally as follows: (i) control, (ii) RT, (iii) AG, (iv) AG+RT and (v) RT+AG group. Histopathological findings and biochemical evaluations, including tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), total oxidant status (TOS), total antioxidant capacity, oxidative stress index (OSI), blood urea nitrogen (BUN), serum creatinine (Cr) and testosterone levels, were determined. MDA, TOS and OSI were significantly higher in RT-treated groups, whereas SOD, CAT, GPX and GSH were significantly lower in these groups when compared with the control rats in the kidney and testis tissue. AG treatment significantly decreased MDA, TOS and OSI levels and increased SOD, CAT, GPX and GSH levels, when compared to the RT-treated groups in both kidney and testis tissue. BUN and Cr levels did not change among the groups, whereas testosterone levels were found as reduced in the RT-treated rats. AG treatment significantly augmented these hazardous effects of RT on testis tissue. According to our results, AG has beneficial effects against RT-induced kidney and testis injury.en_US
dc.identifier.doi10.1111/and.12500
dc.identifier.endpage692en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue6en_US
dc.identifier.pmid26610736en_US
dc.identifier.scopus2-s2.0-84977470253en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage683en_US
dc.identifier.urihttps://doi.org/10.1111/and.12500
dc.identifier.urihttps://hdl.handle.net/11616/97396
dc.identifier.volume48en_US
dc.identifier.wosWOS:000380894600011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectaminoguanidineen_US
dc.subjectkidneyen_US
dc.subjectoxidative stressen_US
dc.subjectradiotherapyen_US
dc.subjecttestisen_US
dc.titleBeneficial effects of aminoguanidine on radiotherapy-induced kidney and testis injuryen_US
dc.typeArticleen_US

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