Spectroscopic, antiproliferative and antiradical properties of Cu(II), Ni(II), and Zn(II) complexes with amino acid based Schiff bases

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dc.authoridŞekerci, Memet/0000-0002-7730-645X
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridKaratepe, Mustafa/0000-0001-6358-5913
dc.authoridKESER, Serhat/0000-0002-9678-1053
dc.authorwosidŞekerci, Memet/AAB-6027-2022
dc.authorwosidSekerci, Memet/W-7894-2018
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidKaratepe, Mustafa/HII-5655-2022
dc.authorwosidKESER, Serhat/V-5951-2018
dc.contributor.authorGenc, Zuhal Karagoz
dc.contributor.authorSelcuk, Sibel
dc.contributor.authorSandal, Suleyman
dc.contributor.authorColak, Naki
dc.contributor.authorKeser, Serhat
dc.contributor.authorSekerci, Memet
dc.contributor.authorKaratepe, Mustafa
dc.date.accessioned2024-08-04T20:39:39Z
dc.date.available2024-08-04T20:39:39Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNovel six Cu(II), Ni(II), and Zn(II) complexes with Schiff bases derived from 4-aminobenzoic acid with terephtaldehyde and amino acids (glycine, beta-alanine). Structures have been proposed from elemental analysis, UV-Vis, IR, NMR, TGA, DTA, and magnetic measurements. Spectroscopic studies suggest that coordination occurs through azomethine nitrogen, hydroxyl group, and carbonyl oxygen of the ligands to the metal ions. The elemental analyses of the complexes where L is Schiff base ligands, are confined to the stoichiometry of the type M2L2(CH3COO)(2) [M = Cu(II)]; and M2L(CH3COO)(2) [M = Ni(II) and Zn(II)]. The cytotoxicity activities of the compounds against human breast carcinoma MCF-7 cell line have been studied. Ligands and their Zn(II) compounds inhibited cell proliferation of MCF-7 cancer cell lines in a dose- and time-dependent manner. The free radical scavenging activity was measured by 1,1-diphenyl-2-picryl-hydrazil. Our results show that the synthesized compounds induced oxidative damage by increasing the lipid peroxidation in yeast since MDA formation was increased, and it could be concluded that the synthesized compounds caused oxidative stress. In addition, the antioxidant activities of the synthesized compounds were very much lower than those of standard antioxidants.en_US
dc.identifier.doi10.1007/s00044-013-0826-7
dc.identifier.endpage2485en_US
dc.identifier.issn1054-2523
dc.identifier.issn1554-8120
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84898771921en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2476en_US
dc.identifier.urihttps://doi.org/10.1007/s00044-013-0826-7
dc.identifier.urihttps://hdl.handle.net/11616/96411
dc.identifier.volume23en_US
dc.identifier.wosWOS:000332153800029en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Birkhauseren_US
dc.relation.ispartofMedicinal Chemistry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpectroscopyen_US
dc.subjectSchiff baseen_US
dc.subjectAntiproliferative activityen_US
dc.subjectDPPHen_US
dc.titleSpectroscopic, antiproliferative and antiradical properties of Cu(II), Ni(II), and Zn(II) complexes with amino acid based Schiff basesen_US
dc.typeArticleen_US

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