Synthesis, structural characterization of silver(I)-NHC complexes and their antimicrobial, antioxidant and antitumor activities

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridHarrath, Abdel Halim/0000-0002-2170-1303
dc.authoridOzdemir, Ismail/0000-0001-6325-0216
dc.authorwosidAl-Tamimi, Jameel H/F-2374-2019
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.authorwosidHarrath, Abdel Halim/K-2166-2014
dc.authorwosidMANSOUR, Lamjed/AAO-6201-2020
dc.authorwosidabutaha, nael/AAX-4443-2021
dc.contributor.authorSlimani, Ichraf
dc.contributor.authorMansour, Lamjed
dc.contributor.authorAbutaha, Nael
dc.contributor.authorHarrath, Abdel Halim
dc.contributor.authorAl-Tamimi, Jameel
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, I
dc.date.accessioned2024-08-04T20:47:03Z
dc.date.available2024-08-04T20:47:03Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo prepare a novel series of silver (I) complexes, the interaction of benzimidazolium salts having their two nitrogen atoms substituted by bulky groups with Ag2O in DMF has been carried out. Their structures were characterized by elemental analyses, H-1 NMR, C-13 NMR and IR spectroscopy techniques. Further, the antibacterial properties of both the salts and their silver(I)-NHC complexes were tested against positive and negative bacteria using the agar dilution procedure. The results show that silver complexes are effective against Salmonella Typhimurium, Listeria monocytogenes, and Micrococcus luteus with moderate to high activity, and their minimum inhibitory concentrations ranging from 0.0024 to 1.25 mg/ml. Moreover, the antioxidant activity determination of these compounds were studied with the DPPH, and compared with (gallic acid GAand butylatedhydroxytoluene BHT ). They exhibited significant antioxidant activities. In addition, the of benzimidazoles salts 2a-j and silver-NHC complexes 3a-j were screened for their antitumor activity. The highest antitumor activity was observed for 3e and 3d Complexes and they exhibited IC50 values 6.85 mu g/mL against MCF-7 and 10.75 mu g/mL against T47D, respectively. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of King Saud University.en_US
dc.description.sponsorshipDeanship of Scientific Research at King Saud University [RG-1435-023]; Inonu University [IU-BAP: FOA-2018-1135]en_US
dc.description.sponsorshipThe authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding this research group No (RG-1435-023) and Inonu University support by Research Fund (IU-BAP: FOA-2018-1135).en_US
dc.identifier.doi10.1016/j.jksus.2019.12.010
dc.identifier.endpage1554en_US
dc.identifier.issn1018-3647
dc.identifier.issn2213-686X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85077377658en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1544en_US
dc.identifier.urihttps://doi.org/10.1016/j.jksus.2019.12.010
dc.identifier.urihttps://hdl.handle.net/11616/99129
dc.identifier.volume32en_US
dc.identifier.wosWOS:000518388400042en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of King Saud University Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectBenzimidazolium saltsen_US
dc.subjectSilver(I)-NHC complexesen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidant activities and antitumor activitiesen_US
dc.titleSynthesis, structural characterization of silver(I)-NHC complexes and their antimicrobial, antioxidant and antitumor activitiesen_US
dc.typeArticleen_US

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