Effects of Propofol or Etomidate on QT Interval During Electroconvulsive Therapy

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dc.authoridErdil, Feray Akgül/0000-0002-7544-3717
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authorwosidErdil, Feray Akgül/ABI-2474-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.contributor.authorErdil, Feray
dc.contributor.authorDemirbilek, Semra
dc.contributor.authorBegec, Zekine
dc.contributor.authorOzturk, Erdogan
dc.contributor.authorErsoy, Mehmet Ozcan
dc.date.accessioned2024-08-04T20:31:18Z
dc.date.available2024-08-04T20:31:18Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Because patients with major depression have an altered autonomic nervous system activity, the risk of arrhythmias and sudden cardiac death may be increased. In addition, electroconvulsive therapy (ECT) may cause an acute rise in QT dispersion, which may predispose to arrhythmias. In this study, we investigated the effects of propofol or etomidate on the corrected QT (QTc) interval during ECT in patients with major depression. Materials and Methods: Fourteen unpremedicated American Society of Anesthesiologists 1 patients, each scheduled for 6 ECT sessions for major depression, were included in a prospective, randomized crossover study The patients randomly received either 1-mg/kg propofol (propofol group) or 0.2-mg/kg etomidate (etomidate group). The mean arterial pressure (MAY), heart rate (HR), and electrocardiogram were recorded before anesthetic induction, 0 and 1 minute after the seizure ended, and 3 and 10 minutes after the seizure ended (T3 and T4, respectively). Results: In the propofol group, the QTc interval was shorter than the baseline at 0 minute after the seizure ended. The QTc interval increased from the baseline at T3 and T4 in the etomidate group. In the etomidate group, the QTc interval was longer at T3 and T4 than that in the propofol group (P < 0.05). In the etomidate group, the HR increased at T3 and T4, but the MAP increased at all measurement times from the baseline value. The HR and the MAP were lower at T3 and T4 in the propofol group than in the etomidate group (P < 0.05). Conclusions: Propofol did not induce prolongation of the QT interval and controlled the hemodynamic response better than etomidate during ECT. Therefore, propofol may be more suitable than etomidate for ECT treatments.en_US
dc.identifier.doi10.1097/YCT.0b013e3181903fa5
dc.identifier.endpage177en_US
dc.identifier.issn1095-0680
dc.identifier.issn1533-4112
dc.identifier.issue3en_US
dc.identifier.pmid19225403en_US
dc.identifier.scopus2-s2.0-70349148248en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage174en_US
dc.identifier.urihttps://doi.org/10.1097/YCT.0b013e3181903fa5
dc.identifier.urihttps://hdl.handle.net/11616/94870
dc.identifier.volume25en_US
dc.identifier.wosWOS:000269708500005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Ecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectelectroconvulsive therapyen_US
dc.subjectanesthesiaen_US
dc.subjectpropofolen_US
dc.subjectetomidateen_US
dc.subjectQT intervalen_US
dc.titleEffects of Propofol or Etomidate on QT Interval During Electroconvulsive Therapyen_US
dc.typeArticleen_US

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