Aqueous humor penetration of topically applied ciprofloxacin, ofloxacin and tobramycin

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dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.contributor.authorDurmaz, B
dc.contributor.authorMarol, S
dc.contributor.authorDurmaz, R
dc.contributor.authorOram, O
dc.contributor.authorHepsen, IF
dc.contributor.authorGunal, S
dc.date.accessioned2024-08-04T20:11:53Z
dc.date.available2024-08-04T20:11:53Z
dc.date.issued1997
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this study was to determine the aqueous humor concentrations of topically applied ciprofloxacin (GAS 86393-32-0), ofloxacin (GAS 82419-36-1) and tobramycin (GAS 79645-27-5). Thirty patients undergoing cataract extraction or trabeculectomy were randomly divided into three groups and each of the group received either 0.3 % ciprofloxacin, ofloxacin or tobramycin topical drops preoperatively. Eyedrops were instilled for six times at a frequency of one drop every 15 minutes, beginning 90 minutes before initiation of the surgery. At the time of surgery, 0.1 mi aqueous fluid was aspirated from the anterior chamber. Concentrations of the antimicrobial agents were determined using the microbroth dilution procedure outlined by the National Committee for Clinical Laboratory Standards. Escherichia coli (ATCC 25922) was used as a standard strain for determination of minimal inhibitory concentrations (MICs). The mean aqueous levels of ciprofloxacin and ofloxacin were found to be 0.092 +/- 0.077 mu g/ml, 0.964 +/- 0.693 mu g/ml, respectively. Tobramycin did not reach the concentration that could be detected by applied method. Conclusion: The mean aqueous humor levels of ofloxacin and ciprofloxacin were more than the MICs levels for most of the ocular pathogens which may cause postoperative endophthalmitis.en_US
dc.identifier.endpage415en_US
dc.identifier.issn0004-4172
dc.identifier.issue4en_US
dc.identifier.pmid9150864en_US
dc.identifier.scopus2-s2.0-0030962285en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage413en_US
dc.identifier.urihttps://hdl.handle.net/11616/93072
dc.identifier.volume47en_US
dc.identifier.wosWOS:A1997WV47000013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEcv-Editio Cantor Verlag Medizin Naturwissenschaftenen_US
dc.relation.ispartofArzneimittel-Forschung/Drug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaqueous humoren_US
dc.subjectCAS 79645-27-5en_US
dc.subjectCAS 82419-36-1en_US
dc.subjectCAS 86393-32-0en_US
dc.subjectciprofloxacinen_US
dc.subjectofloxacinen_US
dc.subjecttobramycinen_US
dc.titleAqueous humor penetration of topically applied ciprofloxacin, ofloxacin and tobramycinen_US
dc.typeArticleen_US

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