Beijing/w and major spoligotype families of Mycobacterium tuberculosis strains isolated from tuberculosis patients in Eastern Turkey

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dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridSola, Christophe N/0000-0003-4672-2140
dc.authoridRASTOGI, NALIN/0000-0002-7199-7747
dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidSola, Christophe N/A-7992-2016
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidRASTOGI, NALIN/AAP-1958-2020
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.contributor.authorOtlu, Baris
dc.contributor.authorDurmaz, Riza
dc.contributor.authorGunal, Selami
dc.contributor.authorSola, Christophe
dc.contributor.authorZozio, Thierry
dc.contributor.authorRastogi, Nalin
dc.date.accessioned2024-08-04T20:31:20Z
dc.date.available2024-08-04T20:31:20Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the Beijing/W family and major phylogenetic clades of Mycobacterium tuberculosis strains Of tuberculosis patients in a city with a tuberculosis incidence higher than the country average. A total of 220 M. tuberculosis strains isolated over a period of more than four years were typed by spoligotyping. Spoligotyping resulted in 64 different patterns, 38 (17.3%) of which were unique, and 26 were clusters including 182 (82.7%) strains. The major shared types were ST 53 (n=55, 25%), ST 41 (LAM7-TUR; n=19, 8.6%), and ST 284 (n=15, 6.8%). The major clades observed ranked in the following order: ill-defined T superfamily (n=112, 50.9%); Latino-American-Mediterranean (LAM; n=33, 15%); Haarlem (n=24, 10.9%); and the S family (n=9, 4.1%). Three strains were in the Beijing family. A high number of strains (33 strains) showed patterns that did not fall within any of the major clades described. M. tuberculosis strains in Malatya have both STs showing a widespread distribution over the world and those restricted to this city, confirming the highly diverse nature of tuberculosis. Our results Suggest that the Beijing clade, which is more prevalent among the strains with MDR and isoniazid resistance, is currently not a problem in Eastern Turkey.en_US
dc.description.sponsorshipTUBITAK [SBAG-HD-43 (105S152)]; European Union and the Regional Council of Guadeloupe and the International Network of the Pasteur Institutes; TUBITAK [SBAG-HD-43 (105S152)]; European Union and the Regional Council of Guadeloupe and the International Network of the Pasteur Institutesen_US
dc.description.sponsorshipThis project was partly supported by TUBITAK (SBAG-HD-43 (105S152)), Ankara, Turkey. TZ was supported through a Ph.D. fellowship awarded by the European Union and the Regional Council of Guadeloupe and the International Network of the Pasteur Institutes.en_US
dc.identifier.endpage263en_US
dc.identifier.issn1121-7138
dc.identifier.issue3en_US
dc.identifier.pmid19845107en_US
dc.identifier.scopus2-s2.0-70349667511en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage255en_US
dc.identifier.urihttps://hdl.handle.net/11616/94883
dc.identifier.volume32en_US
dc.identifier.wosWOS:000270104700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Int Srlen_US
dc.relation.ispartofNew Microbiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTuberculosisen_US
dc.subjectTurkeyen_US
dc.subjectMolecular epidemiologyen_US
dc.subjectSpoligotypingen_US
dc.subjectBeijing genotypeen_US
dc.titleBeijing/w and major spoligotype families of Mycobacterium tuberculosis strains isolated from tuberculosis patients in Eastern Turkeyen_US
dc.typeArticleen_US

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