The role of oxidative stress in bronchoconstriction due to occupational sulfur dioxide exposure

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dc.authoridÇakır, Münire/0000-0001-8650-3722
dc.authorwosidKoksal, Nurhan/AAA-3249-2022
dc.authorwosidÇakır, Münire/AAC-6583-2020
dc.contributor.authorGokirmak, M
dc.contributor.authorYildirim, Z
dc.contributor.authorHasanoglu, HC
dc.contributor.authorKoksal, N
dc.contributor.authorMehmet, N
dc.date.accessioned2024-08-04T20:13:18Z
dc.date.available2024-08-04T20:13:18Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: We previously showed that apricot sulfurization workers (ASW) are exposed to high concentrations of SO2, resulting in an asthma-like syndrome. The aim of this study was to evaluate whether oxidative stress plays a role in the pathogenesis of asthma-like syndrome due to the high concentrations of SO2 exposure in agricultural environment. Methods: Serum antioxidant enzyme activities and malondialdehyde (MDA) concentrations, which are markers of lipid peroxidation, and pulmonary function tests (PFT) were measured in 40 volunteer ASW and compared to 20 healthy control subjects. Results: The superoxide dismutase (SOD, 2.2 +/- 0.6 vs. 3.2 +/- 0.7 U/m), glutathione peroxidase (GSH-Px, 0.6 +/- 0.3 vs. 1.1 +/- 0.3 U/m) and catalase (107.6 +/- 27.4 vs. 152.6 +/- 14.3 k/l) activities in ASW were significantly (p < 0.0001) lower than controls, whereas the malondialdehyde concentration (4.1 +/- 0.9 vs. 1.9 +/- 5.3 nmol/l) was higher in ASW (p < 0.0001). ASW had significant decreases in pulmonary function parameters after exposure. Conclusion: These results show that occupational exposure to high concentrations of SO2 enhances oxidative stress and lipid peroxidation may be considered as a new mechanism of SO2-induced bronchoconstriction. (C) 2003 Elsevier Science B.V. All rights reserved.en_US
dc.identifier.doi10.1016/S0009-8981(03)00117-7
dc.identifier.endpage126en_US
dc.identifier.issn0009-8981
dc.identifier.issn1873-3492
dc.identifier.issue1-2en_US
dc.identifier.pmid12691872en_US
dc.identifier.scopus2-s2.0-0037402656en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.1016/S0009-8981(03)00117-7
dc.identifier.urihttps://hdl.handle.net/11616/93511
dc.identifier.volume331en_US
dc.identifier.wosWOS:000182507200016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsulfur dioxideen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectcatalaseen_US
dc.subjectmalondialdehydeen_US
dc.subjectpulmonary function testsen_US
dc.titleThe role of oxidative stress in bronchoconstriction due to occupational sulfur dioxide exposureen_US
dc.typeArticleen_US

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