Novel silver(I)N-heterocyclic carbene complexes bearing 2-(4-hydroxyphenyl)ethyl group: Synthesis, characterization, and enzyme inhibition properties

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dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridsağlamtaş, rüya/0000-0002-4400-2302
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authorwosidTaslimi, Parham/AAL-2788-2020
dc.authorwosidheravi, nasir ahmad/HTM-4591-2023
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidsağlamtaş, rüya/ABC-8186-2021
dc.authorwosidkaya, rüya/AAB-2401-2021
dc.contributor.authorBehcet, Ayten
dc.contributor.authorAktas, Aydin
dc.contributor.authorGok, Yetkin
dc.contributor.authorKaya, Ruya
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-08-04T20:49:07Z
dc.date.available2024-08-04T20:49:07Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHerein, novel silver-based N-heterocyclic carbene (NHC) complexes bearing 2-(4-hydroxyphenyl)ethyl group were synthesized. Novel Ag(I)NHC complexes were synthesized from the 2-(4-hydroxyphenyl)ethyl-substituted benzimidazolium salts and silver oxide via in situ deprotonation method. The successful formation of all Ag(I)NHC complexes was proved by using H-1 NMR, C-13 NMR, FTIR spectroscopy, and elemental analysis techniques. In addition, their inhibitory effects have been investigated of these substances on acetylcholinesterase (AChE), alpha-glycosidase (alpha-Gly), human carbonic anhydrase I (hCA I), and human carbonic anhydrase II (hCA II) enzymes. It has been seen that all compounds have a better ability to inhibit compared with existing tried inhibitors. Among these, the best inhibitor against AChE enzyme is 1g (K-i : 9.54 +/- 0.98 mu M and IC50 : 17.40), and against alpha-Gly, 1c showed the highest effect (K-i 3.09 +/- 0.36 mu M and IC50 7.91). The best inhibitor against hCA I and hCA II enzymes are 1c and 1g compounds. For hCA I and hCA II, IC50 values were calculated as 17.85 and 9.06 mu M and K-i values were measured as 5.45 +/- 2.02 and 8.99 +/- 2.02 mu M, respectively.en_US
dc.description.sponsorshipInonu Universitesi [FYL-2018-1431]en_US
dc.description.sponsorshipInonu Universitesi, Grant/Award Number: FYL-2018-1431en_US
dc.identifier.doi10.1002/jhet.4199
dc.identifier.endpage611en_US
dc.identifier.issn0022-152X
dc.identifier.issn1943-5193
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85097289926en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage603en_US
dc.identifier.urihttps://doi.org/10.1002/jhet.4199
dc.identifier.urihttps://hdl.handle.net/11616/99661
dc.identifier.volume58en_US
dc.identifier.wosWOS:000596501200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Heterocyclic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic Carbenesen_US
dc.subjectNatural-Products Synthesisen_US
dc.subjectPotential Antitumor-Activityen_US
dc.subjectCrystal-Structureen_US
dc.subjectCarbonic-Anhydraseen_US
dc.subjectCatalytic-Activityen_US
dc.subjectCorresponding Gold(I)en_US
dc.subjectBenzimidazolium Saltsen_US
dc.subjectIn-Vitroen_US
dc.subjectDerivativesen_US
dc.titleNovel silver(I)N-heterocyclic carbene complexes bearing 2-(4-hydroxyphenyl)ethyl group: Synthesis, characterization, and enzyme inhibition propertiesen_US
dc.typeArticleen_US

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