Protective role of selenium and high dose vitamin E against cisplatin - induced Nephrotoxicty in rats

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dc.authorscopusid35363563100
dc.authorscopusid6701713984
dc.authorscopusid7004903750
dc.authorscopusid55150499000
dc.authorscopusid56024971800
dc.authorscopusid55216459900
dc.contributor.authorAksoy A.
dc.contributor.authorKaraoglu A.
dc.contributor.authorAkpolat N.
dc.contributor.authorNaziroglu M.
dc.contributor.authorOzturk T.
dc.contributor.authorKaragoz Z.K.
dc.date.accessioned2024-08-04T20:02:26Z
dc.date.available2024-08-04T20:02:26Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Cisplatin (CDDP) is one of the most active cytotoxic agents in the treatment of cancer. We investigated the effect of selenium (Se) with high dose vitamin E (VE) administration to prevent CDDP-induced nephrotoxicity in rats. Materials and Methods: In this study, 40 female Wistar rats were randomly divided into five equal groups. The first group, which served as the control, was administered physiological saline (2.5 cc/day, 5 days) intraperitoneally (IP), while group A was administered cisplatin (6 mg/kg BW/single dose) plus physiological saline IP. Groups B, C, D received IP five doses of Se (1.5 mg/kg BW), and a high dose of VE (1000 mg/kg BW) (Se-VE) in combination before, simultaneously, and after CDDP, respectively. The rats were sacrificed five days after CDDP administration. Plasma malondialdehide (MDA), glutathione peroxidase (GSH-Px), reduced glutathione (GSH), catalase, urea, creatinine levels, renal histopathological changes were measured. Results: The histopathological injury score, plasma levels of MDA, urea, creatinine were found to increase in group A compared to the control (p<0.05), while plasma levels of GSH-Px, GSH and catalase decreased (p<0.05). In contrast, plasma levels of MDA decreased (p<0.05) in groups B, C, D, which were treated with Se- VE, whereas levels of GSH-Px, GSH were found to increase only for group D (p<0.05). Plasma urea, creatinine levels improved in the treatment groups compared to group A (p<0.001). Histopathological changes caused by CDDP were also significantly improved after Se-VE treatment (p<0.05). Conclusions: Oxidative stress increases with CDDP-induced nephrotoxicity in rats. Se-VE supplementation might thus play a role in the prevention of CDDP-induced nephrotoxicity in patients.en_US
dc.identifier.doi10.7314/APJCP.2015.16.16.6877
dc.identifier.endpage6882en_US
dc.identifier.issn1513-7368
dc.identifier.issue16en_US
dc.identifier.pmid26514460en_US
dc.identifier.scopus2-s2.0-84948184905en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage6877en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2015.16.16.6877
dc.identifier.urihttps://hdl.handle.net/11616/91693
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization for Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectInduced nephropathyen_US
dc.subjectOxidative stressen_US
dc.subjectSeleniumen_US
dc.subjectVitamin Een_US
dc.titleProtective role of selenium and high dose vitamin E against cisplatin - induced Nephrotoxicty in ratsen_US
dc.typeArticleen_US

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