Colonic fibronectin and E-cadherin in mild ulcerative colitis

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dc.contributor.authorSarpdag, F.
dc.contributor.authorYonem, O.
dc.contributor.authorAktas, A.
dc.contributor.authorSeckin, Y.
dc.contributor.authorTuncer, E.
dc.contributor.authorOzer, H.
dc.date.accessioned2024-08-04T20:49:28Z
dc.date.available2024-08-04T20:49:28Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Although fibronectin has an important role in wound repair, nearly no human studies to date have investigated its condition in ulcerative colitis (UC) histologically. E-cadherin plays a critical role in the repair of normal epithelial tissues. This study aims to find out the condition of these two molecules in UC. MATERIAL AND METHODS: The records of 22 UC patients during the period of 2004-2009 were retrospectively analyzed. We also included 24 patients with sporadic colorectal cancer (SCC) and 24 patients with normal colonoscopic biopsies who served as the control group. Colonoscopic biopsies were stained with E-cadherin and fibronectin. RESULTS: The E-cadherin loss was significantly more prominent in the SCC group, followed by the UC group and control group. The situation was reverse for fibronectin. We also observed that while the E-cadherin loss was still ongoing in all of the endoscopically inactive cases, the fibronectin staining resembled the staining pattern of normal individuals in ten out of thirteen UC patients. CONCLUSION: We suggest that the decrease in E-cadherin, even in the inactive period, might be the cause of why UC is not just a compensatory change in repair of inflammation. The results of staining with fibronectin in UC patients were between normal individuals and SCC patients. Further studies are necessary to confirm our results (Tab. 2, Fig. 6, Ref. 15).en_US
dc.identifier.doi10.4149/BLL_2021_056
dc.identifier.endpage335en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue5en_US
dc.identifier.pmid33848183en_US
dc.identifier.scopus2-s2.0-85104345861en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2021_056
dc.identifier.urihttps://hdl.handle.net/11616/99885
dc.identifier.volume122en_US
dc.identifier.wosWOS:000647174500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectulcerative colitisen_US
dc.subjectfibronectinen_US
dc.subjectE-cadherinen_US
dc.titleColonic fibronectin and E-cadherin in mild ulcerative colitisen_US
dc.typeArticleen_US

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