Clinical characteristics and phenotype genotype analysis of Turkish patients with congenital hyperinsulinism
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Eur J Endocrinol
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Congenital hyperinsulinism (CHI) is the commonest cause of hyperinsulinaemic hypoglycaemia in the neonatal,
infancy and childhood periods. Its clinical presentation, histology and underlying molecular biology are extremely
heterogeneous. The aim of this study was to describe the clinical characteristics, analyse the genotype–phenotype
correlations and describe the treatment outcome of Turkish CHI patients.
Design and methods: A total of 35 patients with CHI were retrospectively recruited from four large paediatric endocrine
centres in Turkey. Detailed clinical, biochemical and genotype information was collected.
Results: Diazoxide unresponsiveness was observed in nearly half of the patients (nZ17; 48.5%). Among
diazoxide-unresponsive patients, mutations in ABCC8/KCNJ11 were identified in 16 (94%) patients. Among
diazoxide-responsive patients (nZ18), mutations were identified in two patients (11%). Genotype–phenotype correlation
revealed that mutations in ABCC8/KCNJ11 were associated with an increased birth weight and early age of presentation.
Five patients had p.L1171fs (c.3512del) ABCC8 mutations, suggestive of a founder effect. The rate of detection of
a pathogenic mutation was higher in consanguineous families compared with non-consanguineous families
(87.5 vs 21%; P!0.0001).
Among the diazoxide-unresponsive group, ten patients were medically managed with octreotide therapy and carbohydraterich
feeds and six patients underwent subtotal pancreatectomy. There was a high incidence of developmental delay and
cerebral palsy among diazoxide-unresponsive patients.
Conclusions: This is the largest study to report genotype–phenotype correlations among Turkish patients with CHI.
Mutations in ABCC8 and KCNJ11 are the commonest causes of CHI in Turkish patients (48.6%). There is a higher
likelihood of genetic diagnosis in patients with early age of presentation, higher birth weight and from consanguineous
pedigrees.
Açıklama
Eur J Endocrinol
Anahtar Kelimeler
Kaynak
Eur J Endocrinol
WoS Q Değeri
Scopus Q Değeri
Cilt
170
Sayı
6
Künye
DEMİRBİLEK, H., BHUSHAN, A., MEHMET NURİ, Ö., & AKINCI, A. (2014). Clinical characteristics and phenotype genotype analysis of Turkish patients with congenital hyperinsulinism . Eur J Endocrinol, 170(6), 885–892.
