Effects of resveratrol in ınflammatory arthritis
| dc.contributor.author | Elmalı, Nurzat | |
| dc.contributor.author | Baysal, Özlem | |
| dc.contributor.author | Harma, Ahmet | |
| dc.contributor.author | Esenkaya, İrfan | |
| dc.contributor.author | Mızrak, Bülent | |
| dc.date.accessioned | 2017-05-29T12:04:37Z | |
| dc.date.available | 2017-05-29T12:04:37Z | |
| dc.date.issued | 2007 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description | Inflammation, Vol. 30, Nos. 1Y2, April 2007 ( 2006) | en_US |
| dc.description.abstract | Summary: Nuclear factor kappa B (NF-kB), is a pivotal transcription factor involved in the activation of the TNF-a and IL-1b genes. Activation of NF-kB in synovial cells is a feature seen in arthritis patients. Resveratrol, a polyphenolic, natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-! and IL-1b induced NF-kB activation. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental rabbit inflammatory arthritis model. Materials and methods: Arthritis was induced by intra-articular injection of three times of 50 mg lipopolysaccharide (LPS) at day 0, 4 and 8 at 4-day intervals into the knee joints of rabbits. To the test group, 10 mMol/kg resveratrol in the DMSO was injected in the knees at day 0 and then it was continued once daily for 2 weeks. To the control group the same time and amount of DMSO was injected the knees of rabbits. All rabbits were killed 1 week after the last injection and cartilage tissue and synovium were evaluated with semiquantitative scoring histologically. Results: According to control group in the resveratrol group, significantly decreased cartilage destruction was determined by H&E staining (p = 0.04). Loss of matrix proteoglycan content in the cartilage was much lower, as determined by safranin O staining (p = 0.03). We also observed marked synovial inflammation after intra-articular injection to control knees, but not in the resveratrol treated group knees (p = 0.01). Conclusion: This study suggests that intra-articular injection of resveratrol may protect cartilage against the development of experimentally induced IA. | en_US |
| dc.identifier.citation | N. Elmalı, Ö. Baysal, A. Harma, İ. Esenkaya, And B. Mızrak, “Effects Of Resveratrol İn Inflammatory Arthritis,” Inflammation, Vol. 30, No. 1–2, Pp. 1–6, Mar. 2007. | en_US |
| dc.identifier.doi | 10.1007/s10753-006-9012-0 | en_US |
| dc.identifier.endpage | 6 | en_US |
| dc.identifier.issue | 0 | en_US |
| dc.identifier.startpage | 1 | en_US |
| dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs10753-006-9012-0 | |
| dc.identifier.uri | https://hdl.handle.net/11616/6977 | |
| dc.identifier.volume | 30 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Inflammation | en_US |
| dc.relation.ispartof | Inflammation | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Resveratrol | en_US |
| dc.subject | Cartilage | en_US |
| dc.subject | Synovium | en_US |
| dc.subject | İnflammatory arthritis | en_US |
| dc.title | Effects of resveratrol in ınflammatory arthritis | en_US |
| dc.type | Article | en_US |
