The skin and plasma antioxidant enzyme activities in patients with vitiligo
Yükleniyor...
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi Tıp Fakültesi Derg.(YA. Balkan Medical Journal
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz: Amaç: Oksidatif stresin vitiligo patogenezinde önemli bir faktör olduğu bilinmektedir. Biz bu çalışmada, vitiligolu hastalarda deri ve plasma antioksidan kapasite değişikliği ile vitiligo patogenezi arasındaki olası ilişkiyi araştırmayı amaçladık. Gereç ve Yöntemler: Bu çalışmada 40 vitiligolu hasta ile 15 sağlıklı kontrollere ait normal ve vitiligolu deri ve plasma örneklerinde katalaz, glutatyon peroksidaz ve süperoksit dismutaz enzim aktiviteleri spektrofotometrik metodlarla ölçüldü. Bulgular: Doku enzim aktivitesi (U/mg prt ve Ort±SD olarak) sonuçlarımız; SOD enzimi için sırasıyla tutulum olan deride, tutulum olmayan deride ve kontrol gurubunda 0.64±0.09; 0.89±0.15; 0.41±0.57'dir, GPx enzimi için 170.98±12.35; 182.13±13.48; 121.91±16.03'dür, CAT enzimi için 78.92±10.34; 94.99±10±47; 55.95±7.24'dür. Plazma düzeyleri sırasıyla vitiligo ve control gurubunda SOD enzimi için 37.19±1.53; 39.53±3.32, GPx enzimi için 381.57±12.67; 346.13±21.90 ve CAT enzimi için 66.72±8.86; 61.24±6.32'dir. Sonuç: Vitiligolu hastalarda ve sağlıklı kontrol gurubunda deri ve plasma antioksidan enzim aktiviteleri arasında net bir korelasyon bulunmamaktadır. Özellikle vitiligolu alanda yüksek katalaz ve glutatyon peroksidaz aktivitesi (p<0.05) bu bölgede peroksitler aracılığıyla oluşan oksidatif strese karşı geliştirilen antioksidan yanıtın bir sonucu olabilir.
Abstract: Objective: It is known that oxidative stress could be an important factor in the pathogenesis of vitiligo disease. We aimed to investigate the possible relationship between vitiligo pathogenesis and the change of antioxidant capacity of skin and plasma in patients with vitiligo. Material and Methods: In this study we have examined normal and vitiliginous skin and plasma GPx, SOD and CAT activities by spectrophotometric methods in 40 vitiligo patients and 15 controls. Results: Results of tissue enzyme activities (as U/mg prt and Mean±SD); were 0.64±0.09; 0.89±0.15; 0.41±0.57 for SOD enzyme, 170.98±12.35; 182.13±13.48; 121.91+16.03 for GPx enzyme and 78.92±10.34; 94.99±10+47; 55.95±7.24 for CAT enzyme in involved skin, uninvolved skin and control groups respectively. Plasma levels of these enzymes were 37.19±1.53; 39.53±3.32 SOD enzyme, 381.57±12.67; 346.13±21.90 for GPx and 66.72±8.86; 61.24±6.32 for CAT enzyme in vitiligo and control groups respectively. Conclusion: There is no correlation between skin and plasma antioxidant enzyme activities in vitiligo patients, or in healthy controls. High glutathione peroxidase and catalase activities in vitiligous skin (p<0.05) especially might be a result of anti oxidative stress response against oxidative stress via peroxides.
Abstract: Objective: It is known that oxidative stress could be an important factor in the pathogenesis of vitiligo disease. We aimed to investigate the possible relationship between vitiligo pathogenesis and the change of antioxidant capacity of skin and plasma in patients with vitiligo. Material and Methods: In this study we have examined normal and vitiliginous skin and plasma GPx, SOD and CAT activities by spectrophotometric methods in 40 vitiligo patients and 15 controls. Results: Results of tissue enzyme activities (as U/mg prt and Mean±SD); were 0.64±0.09; 0.89±0.15; 0.41±0.57 for SOD enzyme, 170.98±12.35; 182.13±13.48; 121.91+16.03 for GPx enzyme and 78.92±10.34; 94.99±10+47; 55.95±7.24 for CAT enzyme in involved skin, uninvolved skin and control groups respectively. Plasma levels of these enzymes were 37.19±1.53; 39.53±3.32 SOD enzyme, 381.57±12.67; 346.13±21.90 for GPx and 66.72±8.86; 61.24±6.32 for CAT enzyme in vitiligo and control groups respectively. Conclusion: There is no correlation between skin and plasma antioxidant enzyme activities in vitiligo patients, or in healthy controls. High glutathione peroxidase and catalase activities in vitiligous skin (p<0.05) especially might be a result of anti oxidative stress response against oxidative stress via peroxides.
Açıklama
Anahtar Kelimeler
Kaynak
Trakya Üniversitesi Tıp Fakültesi Derg.(YA. Balkan Medical Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
27
Sayı
4
Künye
BATÇIOĞLU K,HAZNECİ E,ÖZTÜRK İ. Ç,KARABULUT A. B,KARADAĞ N (2010). The skin and plasma antioxidant enzyme activities in patients with vitiligo. Trakya Üniversitesi Tıp Fakültesi Derg.(YA. Balkan Medical Journal, 27(4), 354 - 357.
