Evaluation of the immune response to hepatitis B vaccination in children aged 1-3 years in Malatya, Turkey

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dc.authoridGüneş, Gülsen/0000-0003-2021-7103
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authorwosidGüneş, Gülsen/ABG-9068-2020
dc.authorwosidkaraoğlu, leyla/JQP-1016-2023
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.contributor.authorKaraoglu, L
dc.contributor.authorPehlivan, E
dc.contributor.authorGunes, G
dc.contributor.authorGenc, M
dc.contributor.authorTekerekoglu, SM
dc.contributor.authorErcan, C
dc.contributor.authorEgri, M
dc.date.accessioned2024-08-04T20:13:37Z
dc.date.available2024-08-04T20:13:37Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBy the end of 1998, Turkey had launched the routine vaccination of infants against hepatitis B. The purpose of the study is to evaluate the immune response in a sample of vaccinated children aged 1-3 years in the city of Malatya. A total of 210 vaccinated children 12 to 48 months old were selected for the study with 30 cluster sampling in the city of Malatya, Turkey. The children were visited at their homes during January-April 2002. The information on demographic characteristics, family's and child's medical history was gathered, childrens' weight and height were measured and blood samples were taken. Anti-HBs, HbsAg and anti-HBc titers were assayed by micro-ELIZA from the sera. The mean age of the children was 26.3 months, 100 (47.6%) were male and 110 (52.4%) were female. Overall, 203 (96.7%) children had protective anti-HBs levels (greater than or equal to 10 IU/l), 0.5% showed evidence of natural infection (with positive anti-HBc and anti-HBs titers), 0.5% had acute or chronic infection (with positive HbsAg and anti-HBc titers) and 2.3% were seronegative. Geometric mean titer of anti-HBs among vaccinated children except those who had positive anti-HBc titers was 138.7 mIU/ml (95% Cl :124.7-154.2) and seroconversion rates did not differ by age, sex, anthropometric measurements, time after third dose and place of vaccine administered (P>0.05). The high seroprotection rate over 95% showed that routine infant vaccination program for hepatitis B was successfully carried out in the city Malatya.en_US
dc.identifier.endpage319en_US
dc.identifier.issn1121-7138
dc.identifier.issue4en_US
dc.identifier.pmid14596341en_US
dc.identifier.scopus2-s2.0-0642372740en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://hdl.handle.net/11616/93732
dc.identifier.volume26en_US
dc.identifier.wosWOS:000186196400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLuigi Ponzio E Figlioen_US
dc.relation.ispartofMicrobiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepatitis B vaccinationen_US
dc.subjecthepatitis B immunogenicityen_US
dc.titleEvaluation of the immune response to hepatitis B vaccination in children aged 1-3 years in Malatya, Turkeyen_US
dc.typeArticleen_US

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