The effects of laparascopic cholecystectomy operation on C-reactive protein, hormones, and cytokines

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dc.authoridSevinç, Alper/0000-0002-0499-8918;
dc.authorwosidSari, Ramazan/C-2868-2016
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.authorwosidSevinc, Alper/KFQ-6440-2024
dc.contributor.authorSari, R
dc.contributor.authorSevinc, A
dc.date.accessioned2024-08-04T20:14:45Z
dc.date.available2024-08-04T20:14:45Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe endocrine and immune changes associated with surgery are well documented, but the interaction between them has not been fully evaluated. We, therefore, investigated the possible effects of laparascopic cholecystectomy operation on C-reactive protein, hormones, and cytokines. Thirty-five patients were enrolled in the study (26 females and 9 males, aged 42.4 +/- 16.9 yr, who were admitted to General Surgery Clinic for laparascopic cholecystectomy). Serum C-reactive protein, cortisol, thyroid stimulating hormone, free tri-iodothyronine, free thyroxine, tumor necrosis factor-alpha, interleukin-1beta , soluble interleukin-2 receptor, interleukin-6, and interleukin-8 levels were evaluated 6 h before and after the operation. Postoperative cortisol (p = 0.02), TSH (p = 0.034), tumor necrosis factor-alpha (p = 0.003), soluble interleukin-2 receptor (p = 0.004) were found to be significantly higher than their corresponding preoperative levels. However, postoperative serum free thyroxine (p = 0.011), and free tri-iodothyronine levels (p = 0.001) were decreased when compared with preoperative levels, respectively. No significant difference was observed in C-reactive protein, interleukin-1beta, interleukin-6, and interleukin-8 levels. C-rective protein levels did not change in the early period of the surgical stress. Cytokine responses observed in the early period were found to be conflicting. Cortisol is an important marker of surgical stress which also has close relationship with thyroid functions. (C) 2004, Editrice Kurtis.en_US
dc.identifier.doi10.1007/BF03346253
dc.identifier.endpage110en_US
dc.identifier.issn0391-4097
dc.identifier.issue2en_US
dc.identifier.pmid15129803en_US
dc.identifier.scopus2-s2.0-1942456492en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage106en_US
dc.identifier.urihttps://doi.org/10.1007/BF03346253
dc.identifier.urihttps://hdl.handle.net/11616/93951
dc.identifier.volume27en_US
dc.identifier.wosWOS:000220723500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEditrice Kurtis S R Len_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsurgical stressen_US
dc.subjectC-reactive proteinen_US
dc.subjecthormonesen_US
dc.subjectcytokinesen_US
dc.titleThe effects of laparascopic cholecystectomy operation on C-reactive protein, hormones, and cytokinesen_US
dc.typeArticleen_US

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