Association of oxidative stress and dynamic thiol-disulphide homeostasis with atopic dermatitis severity and chronicity in children: a prospective study

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dc.authorwosidbiçer, cemile/HQZ-5043-2023
dc.contributor.authorUysal, P.
dc.contributor.authorAvcil, S.
dc.contributor.authorNeselioglu, S.
dc.contributor.authorBicer, C.
dc.contributor.authorCatal, F.
dc.date.accessioned2024-08-04T20:44:07Z
dc.date.available2024-08-04T20:44:07Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundOxidative stress (OS) has an important effect on the pathogenesis of atopic dermatitis (AD). Thiols are antioxidants that regulate intracellular redox metabolism and protect keratinocytes against OS damage in the stratum corneum. AimTo investigate dynamic thiol-disulphide homeostasis (dTDH) as a novel OS parameter in children with AD, and its relationship with disease severity and chronicity. MethodsSeverity of AD was determined by using the instruments SCORing Atopic Dermatitis (SCORAD) and Eczema Area And Severity Index (EASI) upon enrolment in the study (SCORAD(1) and EASI(1)) and after 1year (SCORAD(2) and EASI(2)). Native thiol, total thiol and disulphide levels were measured as novel OS parameters, and the ratios of disulphide/native thiol, disulphide/total thiol and native/total thiol were calculated as dTDH. ResultsIn the AD group, the serum disulphide level and the ratios of disulphide/native thiol and disulphide/total thiol were significantly lower than in healthy controls (P=0.01, P<0.01 and P<0.01, respectively). There was no significant association between OS parameters and disease severity (P>0.05). SCORAD(2) and EASI(2) were positively correlated with disulphide/native thiol ratio (r=0.29, P<0.03 and r=0.35, P<0.01, respectively), whereas they were negatively correlated with the native/total thiol ratio (r=-0.30, P=0.02 for both). ConclusionsBoth OS and impaired dTDH were found to be related to childhood AD. None of the OS parameters was associated with AD severity. dTDH is a possible diagnostic tool to predict AD chronicity.en_US
dc.description.sponsorshipDepartment of Clinical Biochemistry (Faculty of Medicine, Yildirim Beyazid University)en_US
dc.description.sponsorshipWe thank M. Alisik (Department of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazid University) for his contribution to the sample analysis. Special thanks to O. Erel for his contribution of financial support to the study via the Department of Clinical Biochemistry (Faculty of Medicine, Yildirim Beyazid University).en_US
dc.identifier.doi10.1111/ced.13219
dc.identifier.endpage130en_US
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue2en_US
dc.identifier.pmid29164676en_US
dc.identifier.scopus2-s2.0-85034764369en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage124en_US
dc.identifier.urihttps://doi.org/10.1111/ced.13219
dc.identifier.urihttps://hdl.handle.net/11616/98036
dc.identifier.volume43en_US
dc.identifier.wosWOS:000424108600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectAntioxidantsen_US
dc.subjectCellsen_US
dc.titleAssociation of oxidative stress and dynamic thiol-disulphide homeostasis with atopic dermatitis severity and chronicity in children: a prospective studyen_US
dc.typeArticleen_US

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