Pan-Immune Inflammation Value and Clinical Outcomes in Subacute Sclerosing Panencephalitis: A Retrospective Study

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dc.contributor.authorOzgor, Bilge
dc.contributor.authorSahin, Murat Caglar
dc.contributor.authorBicakcioglu, Isinsu
dc.contributor.authorYucel, Gul
dc.contributor.authorKaradag, Meral
dc.contributor.authorGungor, Serdal
dc.date.accessioned2026-04-04T13:30:55Z
dc.date.available2026-04-04T13:30:55Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractSubacute sclerosing panencephalitis (SSPE) is a rare, progressive, and fatal neurological disorder caused by persistent measles virus infection. Reliable prognostic biomarkers remain limited. Systemic inflammation has been implicated in the pathogenesis of neuroinfectious diseases, and hematology-derived indices are increasingly recognized as accessible markers of inflammatory burden. This retrospective case-control study was conducted at & Idot;n & ouml;n & uuml; University Faculty of Medicine, Malatya, T & uuml;rkiye, between 2010 and 2025, including 40 pediatric patients with SSPE and 40 age- and sex-matched healthy controls. Demographic and laboratory data were retrieved from institutional records, and disease severity was classified according to Jabbour stages. Compared with controls, patients with SSPE had significantly higher pan-immune inflammation value (PIV: 710.5 [320-1050] vs. 280.0 [150-460], p < 0.001), systemic immune-inflammation index (SII: 640.0 [310-1240] vs. 410.0 [210-720], p = 0.02), and neutrophil-to-lymphocyte ratio (NLR: 2.1 [1.2-3.8] vs. 1.6 [1.0-2.5], p = 0.03), along with lower lymphocyte counts (p = 0.04). Elevated PIVs were strongly associated with advanced Jabbour stages, impaired ambulation, and a higher case-fatality ratio (35%). Multivariate regression identified PIV as an independent predictor of death (OR: 3.25, 95% CI: 1.45-7.28, p = 0.004), and receiver operating characteristic analysis demonstrated superior discriminative accuracy of PIV (AUC = 0.87) compared with other indices. These findings suggest that PIV, a simple and inexpensive biomarker derived from routine blood tests, may provide useful prognostic information in SSPE and aid early risk stratification. Further multicenter, prospective studies are warranted to validate its clinical utility.
dc.identifier.doi10.3390/v18010018
dc.identifier.issn1999-4915
dc.identifier.issue1
dc.identifier.pmid41600783
dc.identifier.scopus2-s2.0-105028481187
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/v18010018
dc.identifier.urihttps://hdl.handle.net/11616/108471
dc.identifier.volume18
dc.identifier.wosWOS:001672827600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofViruses-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectsubacute sclerosing panencephalitis
dc.subjectmeasles virus
dc.subjectpan-immune inflammation value
dc.subjectprognosis
dc.subjectinflammatory biomarker
dc.titlePan-Immune Inflammation Value and Clinical Outcomes in Subacute Sclerosing Panencephalitis: A Retrospective Study
dc.typeArticle

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