Concurrent congenital hemophilia B and acquired hemophilia A: a unique case report

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dc.contributor.authorCirik, Salih
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorBerber, Ilhami
dc.contributor.authorHidayet, Emine
dc.contributor.authorBicim, Soykan
dc.date.accessioned2024-08-04T20:56:12Z
dc.date.available2024-08-04T20:56:12Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCongenital hemophilia B is a rare X-linked recessive bleeding disorder caused by factor IX deficiency. Acquired hemophilia A is a rare, acquired bleeding disorder that presents with new-onset bleeding, especially in older adults, due to the development of auto-antibodies against factor VIII (FVIII). This case report presents the medical management of a patient with congenital hemophilia B and acquired hemophilia A. We highlight the limitations of maintaining factor levels with factor replacement therapy alone, particularly in hemophilia patients who have developed factor inhibitors. In addition, we draw attention to the need for dose escalation, the cost, and the need for immune-tolerance induction therapy. This case illustrates that when the current diagnosis does not explain the full clinical picture and laboratory data are inadequate, it is important to continue to seek alternative diagnoses and cost-effective treatment.en_US
dc.identifier.doi10.1097/MBC.0000000000001306
dc.identifier.endpage285en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue5en_US
dc.identifier.pmid38700550en_US
dc.identifier.scopus2-s2.0-85197977926en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage282en_US
dc.identifier.urihttps://doi.org/10.1097/MBC.0000000000001306
dc.identifier.urihttps://hdl.handle.net/11616/102107
dc.identifier.volume35en_US
dc.identifier.wosWOS:001265114600006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacquired factor XIII deficiencyen_US
dc.subjectacquired hemophilia Aen_US
dc.subjectfactor IX deficiencyen_US
dc.subjectfactor replacement therapyen_US
dc.subjecthemophilia Ben_US
dc.titleConcurrent congenital hemophilia B and acquired hemophilia A: a unique case reporten_US
dc.typeArticleen_US

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