Increased Mean Platelet Volume in Behcet's Disease with Thrombotic Tendency

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dc.authoridAkaycan, Jülide/0000-0002-9174-6777
dc.authoridCansel, Mehmet/0000-0003-4740-4371
dc.authoridPekdemir, Hasan/0000-0002-4913-5120
dc.authorwosidAkaycan, Jülide/ABI-2397-2020
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.authorwosidCansel, Mehmet/ABI-6324-2020
dc.authorwosidErmis, Necip/A-5184-2018
dc.authorwosidPekdemir, Hasan/ABI-6096-2020
dc.contributor.authorAcikgoz, Nusret
dc.contributor.authorKarincaoglu, Yelda
dc.contributor.authorErmis, Necip
dc.contributor.authorYagmur, Juelide
dc.contributor.authorAtas, Halil
dc.contributor.authorKurtoglu, Ertugrul
dc.contributor.authorCansel, Mehmet
dc.date.accessioned2024-08-04T20:32:31Z
dc.date.available2024-08-04T20:32:31Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe relationship between Behcet's disease (BD) and platelet aggregation has not sufficiently been investigated yet. Mean platelet volume (MPV) is a marker of platelet function, and the increase in MPV has been identified as an independent risk factor of recurrent vascular events. BD is characterized by a relapsing vasculitis of the venous as well as arterial thrombosis. However, the precise pathogenic mechanisms underlying thrombotic tendency in BD are not known. We hypothesized that there might be an association between thrombotic complication and MPV in these patients. Therefore, we investigated activation of platelets in patients with BD using a simple marker, MPV, the most accurate measure of platelet size. A total of 60 patients with BD and 40 age- and gender-matched controls were included. The BD patients were divided into subgroups based on the presence (n = 22) or absence of thrombosis (n = 38) and clinically active (n = 30) or inactive (n = 30) state. MPV was higher in patients with BD than controls (8.14 +/- 0.8 vs. 7.48 +/- 0.3 fl, p = 0.001). Among BD patients, MPV was larger in patients with thrombosis than those without thrombosis (8.45 +/- 1.0 vs. 7.96 +/- 0.7 fl, p = 0.038). However, there was no significant difference in MPV between BD patients with active and inactive states. The increase in MPV is independent of the disease activity, and the presence of thrombosis is associated with higher MPV in BD patients. Therefore, antiplatelet therapy may be useful to prevent thrombotic complications in BD patients.en_US
dc.identifier.doi10.1620/tjem.221.119
dc.identifier.endpage123en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue2en_US
dc.identifier.pmid20484842en_US
dc.identifier.scopus2-s2.0-77955484354en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.221.119
dc.identifier.urihttps://hdl.handle.net/11616/95101
dc.identifier.volume221en_US
dc.identifier.wosWOS:000278289100005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmean platelet volumeen_US
dc.subjectBehcet's diseaseen_US
dc.subjectplateleten_US
dc.subjectthrombosisen_US
dc.subjectvasculitisen_US
dc.titleIncreased Mean Platelet Volume in Behcet's Disease with Thrombotic Tendencyen_US
dc.typeArticleen_US

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