In vitro comparison of four tocolytic agents, alone and in combination

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dc.authorscopusid7006942866
dc.authorscopusid55886237400
dc.authorscopusid7102893402
dc.authorscopusid6507468651
dc.authorscopusid7005901536
dc.contributor.authorSaade G.R.
dc.contributor.authorTaskin O.
dc.contributor.authorBelfort M.A.
dc.contributor.authorErturan B.
dc.contributor.authorMoise K.J.
dc.contributor.authorJr.
dc.date.accessioned2024-08-04T19:59:12Z
dc.date.available2024-08-04T19:59:12Z
dc.date.issued1994
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To compare the tocolytic effects or magnesium sulfate, ritodrine, terbutaline, and nifedipine on human myometrial strips. Methods: Myometrial strips were suspended in organ chambers for isotonic measurements and contracted with KCl. Strips from nonpregnant patients were used to obtain concentration-response curves. Myometrial strips from pregnant uteri were then exposed to the molar concentrations causing 50% relaxation in the nonpregnant tissues. Results: In strips from nonpregnant patients, nifedipine was found to be the most potent tocolytic. Using strips from nonlaboring patients, nifedipine caused relaxation similar to ritodrine, and both were more effective than magnesium sulfate or terbutaline. Combinations were more effective than single agents. These agents were found to be equally less effective in myometrial strips from laboring patients. Conclusions: Nifedipine, alone or in combination, relaxes myometrial strips more effectively than the other agents studied. Myometrial strips from laboring patients are more resistant to inhibition, with none of the agents being superior. © 1994 by The American College of Obstetricians and Gynecologists.en_US
dc.identifier.endpage378en_US
dc.identifier.issn0029-7844
dc.identifier.issue3en_US
dc.identifier.pmid8058234en_US
dc.identifier.scopus2-s2.0-0028095011en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage374en_US
dc.identifier.urihttps://hdl.handle.net/11616/90450
dc.identifier.volume84en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofObstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmagnesium sulfateen_US
dc.subjectnifedipineen_US
dc.subjectritodrineen_US
dc.subjectterbutalineen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug effecten_US
dc.subjectdrug efficacyen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjecthuman tissueen_US
dc.subjectmyometriumen_US
dc.subjectpremature laboren_US
dc.subjectpriority journalen_US
dc.subjecttocolysisen_US
dc.subjectAdulten_US
dc.subjectComparative Studyen_US
dc.subjectDose-Response Relationship, Drugen_US
dc.subjectDrug Therapy, Combinationen_US
dc.subjectFemaleen_US
dc.subjectHumanen_US
dc.subjectIn Vitroen_US
dc.subjectLabor, Obstetricen_US
dc.subjectMagnesium Sulfateen_US
dc.subjectMyometriumen_US
dc.subjectNifedipineen_US
dc.subjectPregnancyen_US
dc.subjectRitodrineen_US
dc.subjectTerbutalineen_US
dc.subjectTocolytic Agentsen_US
dc.subjectUterine Contractionen_US
dc.titleIn vitro comparison of four tocolytic agents, alone and in combinationen_US
dc.typeArticleen_US

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