Design and synthesis of some thiazolotriazolyl esters as anti-inflammatory and analgesic agents

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dc.authoridAKTAY, Goknur/0000-0002-1646-8674
dc.authorwosidAytac, Peri/AGY-9153-2022
dc.authorwosidGürsoy, Şule/JPW-8593-2023
dc.contributor.authorTozkoparan, Birsen
dc.contributor.authorAytac, S. Peri
dc.contributor.authorGursoy, Sule
dc.contributor.authorAktay, Goknur
dc.date.accessioned2024-08-04T20:35:55Z
dc.date.available2024-08-04T20:35:55Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn order to develop potent analgesic/anti-inflammatory compounds with reduced ulcerogenic risk, a series of thiazolotriazolyl-carboxylic and acetic acid esters were synthesized and characterized by spectral and elementary analysis. All synthesized compounds were screened for in vivo anti-inflammatory activities in mice by carregeenan-induced paw edema model. The compounds showing 20% reduction in paw edema were also evaluated for their analgesic activities by acetic acid-induced writhing test and the gastric ulceration risk by determining the lipid peroxidation level in stomachs. Among the compounds tested, compounds 1, 4, 6, 7, 8, 1a, 2a, 3a, 4a, 7a, 2b, and 8b showed moderate-to-good anti-inflammatory activity at various doses in any of the measurement intervals. Compounds 7a, 2b, and 8b were the most actives of the series in analgesic activity test. Moreover, compounds 1, 4, and 8 were found to be safe in stomach in respect of free radical production.en_US
dc.description.sponsorshipHacettepe University Research Center [0701301001]en_US
dc.description.sponsorshipWe are grateful Hacettepe University Research Center for its financial supports (P. N.: 0701301001).en_US
dc.identifier.doi10.1007/s00044-010-9508-x
dc.identifier.endpage201en_US
dc.identifier.issn1054-2523
dc.identifier.issn1554-8120
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84861852874en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage192en_US
dc.identifier.urihttps://doi.org/10.1007/s00044-010-9508-x
dc.identifier.urihttps://hdl.handle.net/11616/95675
dc.identifier.volume21en_US
dc.identifier.wosWOS:000298882100008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Birkhauseren_US
dc.relation.ispartofMedicinal Chemistry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiazolotriazolyl-carboxylic acid estersen_US
dc.subjectThiazolotriazolyl acetic acid estersen_US
dc.subjectAnalgesic/antiinflammatory activityen_US
dc.titleDesign and synthesis of some thiazolotriazolyl esters as anti-inflammatory and analgesic agentsen_US
dc.typeArticleen_US

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