Phytogenic Silver and Copper Nanoparticles from Morus nigra L. Leaf as Multifunctional Agents: Antioxidant, Antidiabetic, Antimicrobial, and Anticancer Potency

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dc.contributor.authorDerin, Dilek Çam
dc.contributor.authorBaltaci, Cemalettin
dc.contributor.authorAkmeşe, Osman
dc.contributor.authorTaskin, Irmak Icen
dc.contributor.authorKarpuz, Omer
dc.contributor.authorGültekin, Enes
dc.contributor.authorSever, Meryem Rüveyda
dc.date.accessioned2026-04-04T13:14:44Z
dc.date.available2026-04-04T13:14:44Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThe growing need for eco-friendly nanomaterials has directed attention toward plant-based green synthesis as a sustainable approach for biomedical applications. This study reports the biosynthesis of silver (YAgNPs) and copper nanoparticles (YCuNPs) using Morus nigra L. leaf extract and evaluates their multifunctional properties. The nanoparticles were produced under alkaline aqueous conditions, and their crystalline nature and nanoscale morphology were confirmed by standard structural and elemental analyses. Both YAgNPs and YCuNPs exhibited enhanced antioxidant capacities compared to the crude extract. YAgNPs showed the highest ferric reducing antioxidant power (250.33 mg FeSO₄/g), while YCuNPs demonstrated superior DPPH radical scavenging activity (114.12 mg AAE/g). In antidiabetic assays, YAgNPs strongly inhibited α-amylase (IC₅₀ = 112.02 μg/mL) and α-glucosidase (IC₅₀ = 38.27 μg/mL), approaching the potency of acarbose. Antimicrobial analysis revealed distinct activity profiles: YAgNPs were highly effective in broth cultures with low MIC and MBC values (0.09–0.18 mg/mL against B. subtilis and E. coli), whereas YCuNPs achieved larger inhibition zones in diffusion assays. Checkerboard testing confirmed synergistic interactions between nanoparticles and antibiotics, with FICI values ≤0.5 against E. faecium, E. coli, and P. aeruginosa, highlighting their ability to enhance antibiotic efficacy. YAgNPs exhibited notable cytotoxic effects against HeLa and HCT116 cancer cell lines, with IC₅₀ values of 9.84 and 6.83 μg/mL, respectively. In contrast, YCuNPs displayed weaker anticancer activity. Overall, these findings demonstrate that M. nigra derived nanoparticles combine antioxidant, antidiabetic, antimicrobial, and anticancer activities with synergistic antibiotic-enhancing effects, underscoring their potential as sustainable, multifunctional therapeutic agents.
dc.identifier.doi10.51435/turkjac.1738363
dc.identifier.endpage337
dc.identifier.issn2687-6698
dc.identifier.issue3
dc.identifier.startpage321
dc.identifier.trdizinid1388458
dc.identifier.urihttps://doi.org/10.51435/turkjac.1738363
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1388458
dc.identifier.urihttps://hdl.handle.net/11616/107444
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Analytical Chemistry (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250329
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectMikrobiyoloji
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyoloji
dc.subjectOnkoloji
dc.titlePhytogenic Silver and Copper Nanoparticles from Morus nigra L. Leaf as Multifunctional Agents: Antioxidant, Antidiabetic, Antimicrobial, and Anticancer Potency
dc.typeArticle

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