Comparison of the antioxydant enzyme levels with the degree of dysfunction in patients with myocardial dysfunction

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dc.authorscopusid6603951627
dc.authorscopusid59096587100
dc.authorscopusid34770872600
dc.authorscopusid6603650693
dc.authorscopusid6701345397
dc.authorscopusid6602415155
dc.contributor.authorSezgin N.
dc.contributor.authorSezgin A.T.
dc.contributor.authorKarabulut A.
dc.contributor.authorTopal E.
dc.contributor.authorBarutçu I.
dc.contributor.authorGözükara E.M.
dc.date.accessioned2024-08-04T20:02:04Z
dc.date.available2024-08-04T20:02:04Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Myocardial dysfunction in patients with cardiomyopathy is proposed to occur due to membrane changes caused by oxidative stress. In our study we evaluate whether there is any relation between the degree of myocardial dysfunction and antioxicant enzymes. Methods: We studied superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase (CAT) enzyme activities from blood samples of 60 patients (30 patients had ejection fraction (EF) <%35 and 30 patients had EF= %35-50) who have myocardial dysfunction according to clinical findings and two dimensional echocardiography, and 20 healthy volunteers. Results: We found erythrocyte SOD enzyme activities of patients with EF <%35 (group 3) were significantly lower than in control subjects (group 1) (p=0.01). However in group 2 patients (EF=%35-50), erythrocyte SOD activities were found to be lower than in control subjects but this difference was not significant. Erythrocte CAT and GSHPx enzyme activities of group 3 were also significantly lower than in control group (p=0.04 and p=0.02 respectively). Conclusion: In conclusion, reactive oxygen species play a significant role in the initiation and the progression of congestive heart failure. Increased free radicals levels may cause myocardial muscle dysfunction.en_US
dc.identifier.endpage134en_US
dc.identifier.issn1302-8723
dc.identifier.issue2en_US
dc.identifier.pmid15165947en_US
dc.identifier.scopus2-s2.0-3042552332en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage130en_US
dc.identifier.urihttps://hdl.handle.net/11616/91400
dc.identifier.volume4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant enzymeen_US
dc.subjectFree oxygen radicalsen_US
dc.subjectIschemic cardiomyopathyen_US
dc.titleComparison of the antioxydant enzyme levels with the degree of dysfunction in patients with myocardial dysfunctionen_US
dc.title.alternativeMiyokard Disfonksiyonu Olan Hastalarda Disfonksiyonun Derecesi ile Antioksidan Enzim Düzeylerinin Karşilaştirilmasien_US
dc.typeArticleen_US

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