An Eco-friendly Approach to C-H Bond Activation through Microwave Irradiation Employing Synthesized Palladium-PEPPSI-NHC Complexes

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dc.contributor.authorSlimani, Ichraf
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorAlici, Bulent
dc.contributor.authorArslan, Nahide Burcu
dc.contributor.authorOzdemir, Namik
dc.date.accessioned2026-04-04T13:34:42Z
dc.date.available2026-04-04T13:34:42Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThe formation of carbon-carbon bonds constitutes one of the most fundamental synthetic operations in organic chemistry. Arylation of heteroarenes through C-H bond activation using Pd-PEPPSI complexes as catalysts was widely performed using the classical heating method. However, the use of this heating method is associated with an unfavorable environmental profile, as they generally use a high reaction temperature, a high catalyst load, and a long reaction time. Herein, we disclose the synthesis of new Pd-PEPPSI-NHC complexes bearing NHC ligands, which were tested as a catalyst in the arylation of 2-acethylfuran and 2-acethylthiophene with different aryl bromides using microwave irradiation. This novel method provides access to the biaryl scaffolds in good yields using 0.5 mol % as catalyst loading and at 110 degrees C. The structure of the five palladium(II) complexes has been elucidated through NMR 1H, 13C, and FT-IR spectroscopy. Furthermore, the square-planar geometry of the organometallic ion was confirmed by single-crystal X-ray diffraction carried out on complexes 3b and 3e.
dc.description.sponsorshipIn?n? ?niversitesi [TUBITAK, 2216B-TWAS, FBG-2023-3273]; Technological and Scientific Research Council of Turkey
dc.description.sponsorshipThis work was supported by the Technological and Scientific Research Council of Turkey (TUBITAK) for the Post-Doc Research Fellowship Program (2216B-TWAS) and Inonu University, FBG-2023-3273.
dc.identifier.doi10.1021/acsomega.5c04713
dc.identifier.endpage40008
dc.identifier.issn2470-1343
dc.identifier.issue35
dc.identifier.orcid0000-0001-6325-0216
dc.identifier.orcid0000-0003-3371-9874
dc.identifier.orcid0000-0003-3201-3597
dc.identifier.pmid40949214
dc.identifier.scopus2-s2.0-105015376966
dc.identifier.scopusqualityQ1
dc.identifier.startpage39994
dc.identifier.urihttps://doi.org/10.1021/acsomega.5c04713
dc.identifier.urihttps://hdl.handle.net/11616/109357
dc.identifier.volume10
dc.identifier.wosWOS:001563115100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Omega
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCross-Coupling Reactions
dc.subjectHeterocyclic Carbene Complexes
dc.subjectCatalyzed Direct Arylation
dc.subjectAryl Bromides
dc.subjectPd-Peppsi
dc.subjectSuzuki
dc.subjectLigands
dc.subjectFunctionalization
dc.subjectWater
dc.subjectHeteroarenes
dc.titleAn Eco-friendly Approach to C-H Bond Activation through Microwave Irradiation Employing Synthesized Palladium-PEPPSI-NHC Complexes
dc.typeArticle

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