Thrombotic thrombocytopenic purpura presenting with pathologic fracture: a case report

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dc.authoridÜnlü, Serkan/0000-0001-7535-0812
dc.authoridErtem, Kadir/0000-0002-8892-494X
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridBERBER, Ilhami/0000-0003-3312-8476
dc.authorwosidÜnlü, Serkan/AAD-2212-2022
dc.authorwosidErtem, Kadir/ABG-9780-2020
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidBERBER, Ilhami/ABI-6231-2020
dc.contributor.authorBerber, Ilhami
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorUnlu, Serkan
dc.contributor.authorErtem, Kadir
dc.contributor.authorNizam, Ilknur
dc.date.accessioned2024-08-04T20:40:16Z
dc.date.available2024-08-04T20:40:16Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThrombotic thrombocytopenic purpura is an acute syndrome with abnormalities in multiple organ systems, which becomes manifest with microangiopathic hemolytic anemia and thrombocytopenia. The hereditary or acquired deficiency of ADAMTS-13 activity leads to an excess of high molecular weight von Willebrand factor multimers in plasma, leading to platelet aggregation and diffuse intravascular thrombus formation, resulting in thrombotic thrombocytopenic purpura. Thrombotic lesions occurring in TTP leads to ischemia and convulsion. Depending on the properties of the bony tissue, fractures are divided into three groups as traumatic, pathological, and stress fractures. A pathologic fracture is a broken bone caused by disease leading to weakness of the bone. This process is most commonly due to osteoporosis, but may also be due to other pathologies such as cancer, infections, inherited bone disorders, or a bone cyst. We herein report a case with a pathologic fracture due to convulsion secondary to thrombotic thrombocytopenic pupura. Thrombotic lesions occurring in TTP may lead to ischemia and convulsion, as in our patient and pathological fractures presented in our case report may occur as a result of severe muscle contractions associated with convulsive activity. Thrombotic thrombocytopenic pupura is a disease that involves many organ systems and thus may have a very wide spectrum of clinical presentations. (C) 2014 Published by Elsevier Ltd.en_US
dc.identifier.doi10.1016/j.transci.2014.05.003
dc.identifier.endpage76en_US
dc.identifier.issn1473-0502
dc.identifier.issue1en_US
dc.identifier.pmid25113918en_US
dc.identifier.scopus2-s2.0-84930041388en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2014.05.003
dc.identifier.urihttps://hdl.handle.net/11616/96798
dc.identifier.volume51en_US
dc.identifier.wosWOS:000345185700018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThrombotic thrombocytopenic purpuraen_US
dc.subjectPathologic fractureen_US
dc.subjectConvulsionen_US
dc.titleThrombotic thrombocytopenic purpura presenting with pathologic fracture: a case reporten_US
dc.typeArticleen_US

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