Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy
Yükleniyor...
Dosyalar
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACTA CIRURGICA BRASILEIRA, ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To investigate thymoquinone, curcumin and a combination of these two drugs were effective or not at the growth of liver.
Methods: Forty female Wistar-Albino rats distributed into five groups of eight rats each, control, thymoquinone, curcumin, and thymoquinone/curcumin groups. Pathological specimens were studied using the Ki-67 Proliferation Index(PI); and arginase(Arg), tissue plasminogen activator(tPA), ceruloplasmin(Cer) and nitric oxide(NO) were studied in biochemical analysis.
Results: Our results showed that Ki-67 proliferation index was low in Groups 1. The proliferation coefficient was significantly higher in the Group 2 and Group 4 than in the Group 1 and Group 3.(P < 0.001 between Groups 1 and 2, 1 and 4, and 3 and 4). There was no difference between Groups 2 and 4 (P = 1). The results of the biochemical Arg, tPA and Cer test showed statistically between the Group 1 and Group 2. NO showed significant differences Group 1 and 3.
Conclusions: Thymoquinone and curcumin both have known positive effects on the organism. Histological and biochemical tests showed that thymoquinone is more effective than curcumin.
Açıklama
Anahtar Kelimeler
Nıgella-Satıva, Hepatocellular-Carcınoma, Remnant, Prolıferatıon, Toxıcıty, Volume, Mıce, Oıl
Kaynak
Acta cırurgıca brasıleıra
WoS Q Değeri
Scopus Q Değeri
Cilt
33
Sayı
2
Künye
Yılmaz, M. (2018). Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy. Cilt:33 Sayı:2, 110-116 ss.
