Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy
| dc.contributor.author | Yılmaz, Mehmet | |
| dc.date.accessioned | 2019-07-12T12:21:37Z | |
| dc.date.available | 2019-07-12T12:21:37Z | |
| dc.date.issued | 2018 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Purpose: To investigate thymoquinone, curcumin and a combination of these two drugs were effective or not at the growth of liver. Methods: Forty female Wistar-Albino rats distributed into five groups of eight rats each, control, thymoquinone, curcumin, and thymoquinone/curcumin groups. Pathological specimens were studied using the Ki-67 Proliferation Index(PI); and arginase(Arg), tissue plasminogen activator(tPA), ceruloplasmin(Cer) and nitric oxide(NO) were studied in biochemical analysis. Results: Our results showed that Ki-67 proliferation index was low in Groups 1. The proliferation coefficient was significantly higher in the Group 2 and Group 4 than in the Group 1 and Group 3.(P < 0.001 between Groups 1 and 2, 1 and 4, and 3 and 4). There was no difference between Groups 2 and 4 (P = 1). The results of the biochemical Arg, tPA and Cer test showed statistically between the Group 1 and Group 2. NO showed significant differences Group 1 and 3. Conclusions: Thymoquinone and curcumin both have known positive effects on the organism. Histological and biochemical tests showed that thymoquinone is more effective than curcumin. | en_US |
| dc.identifier.citation | Yılmaz, M. (2018). Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy. Cilt:33 Sayı:2, 110-116 ss. | en_US |
| dc.identifier.doi | 10.1590/s0102-865020180020000002 | en_US |
| dc.identifier.endpage | 116 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 110 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/12579 | |
| dc.identifier.volume | 33 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | ACTA CIRURGICA BRASILEIRA, ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL | en_US |
| dc.relation.ispartof | Acta cırurgıca brasıleıra | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Nıgella-Satıva | en_US |
| dc.subject | Hepatocellular-Carcınoma | en_US |
| dc.subject | Remnant | en_US |
| dc.subject | Prolıferatıon | en_US |
| dc.subject | Toxıcıty | en_US |
| dc.subject | Volume | en_US |
| dc.subject | Mıce | en_US |
| dc.subject | Oıl | en_US |
| dc.title | Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy | en_US |
| dc.type | Article | en_US |
