Spectroscopy analysis of uterine leiomyomas before and after treatment with GnRH-a

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dc.contributor.authorHasçalık, Şeyma
dc.contributor.authorÇelik, Önder
dc.contributor.authorSaraç, Kaya
dc.contributor.authorAlkan, Alpay
dc.contributor.authorMızrak, Bülent
dc.date.accessioned2020-06-02T10:37:18Z
dc.date.available2020-06-02T10:37:18Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.descriptionÖz: Başlık (İngilizce): Öz (İngilizce):MR spectroscopy uses the same hardware as magnetic resonance imaging but provides information at the biochemical level. It has been used to measure proton-containing compounds, such as amino acids, fatty acids, organic acids, sugars and other metabolic active compounds in tissue specimens. Before and after GnRH-a treatment we measured lipid, lactate, creatine and choline concentrations in two patients with uterine leiomyomas using single-voxel proton MR spectroscopy. Subcutaneous goserelin acetate injection was performed at least two times every 4 weeks before surgery. Spectroscopy was performed 3 weeks later last goserelin acetate injection. The MR spectroscopy results of leiomyomas before and after GnRH-a treatment were compared. Before GnRH-a treatment, spectral analysis of each patients showed only choline signals. After GnRH-a treatment, spectrum of both patients showed lipid peaks but the other signals were not observed. The presence of lipid signals and absence of other signals suggest a diffuse metabolic defect in association with GnRHa treatment, possibly consistent with decrease in myoflaments, and increase in apopitosis and necrosis.en_US
dc.description.abstractÖz: Başlık (İngilizce): Öz (İngilizce): MR spectroscopy uses the same hardware as magnetic resonance imaging but provides information at the biochemical level. It has been used to measure proton-containing compounds, such as amino acids, fatty acids, organic acids, sugars and other metabolic active compounds in tissue specimens. Before and after GnRH-a treatment we measured lipid, lactate, creatine and choline concentrations in two patients with uterine leiomyomas using single-voxel proton MR spectroscopy. Subcutaneous goserelin acetate injection was performed at least two times every 4 weeks before surgery. Spectroscopy was performed 3 weeks later last goserelin acetate injection. The MR spectroscopy results of leiomyomas before and after GnRH-a treatment were compared. Before GnRH-a treatment, spectral analysis of each patients showed only choline signals. After GnRH-a treatment, spectrum of both patients showed lipid peaks but the other signals were not observed. The presence of lipid signals and absence of other signals suggest a diffuse metabolic defect in association with GnRHa treatment, possibly consistent with decrease in myoflaments, and increase in apopitosis and necrosis.en_US
dc.identifier.citationŞeyma H., Önder Ç., Kaya S., Alpay A., Bülent M. (2005). Spectroscopy analysis of uterine leiomyomas before and after treatment with GnRH-a, GORM:Gynecology Obstetrics & Reproductive Medicine, GORM:Gynecology Obstetrics & Reproductive Medicineen_US
dc.identifier.endpage144en_US
dc.identifier.issn1300-4751
dc.identifier.issn2602-4918
dc.identifier.issue2en_US
dc.identifier.startpage141en_US
dc.identifier.trdizinid58688en_US
dc.identifier.urihttps://hdl.handle.net/11616/15644
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/58688
dc.identifier.volume11en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherGORM:Gynecology Obstetrics & Reproductive Medicineen_US
dc.relation.ispartofGORM:Gynecology Obstetrics & Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKadın Hastalıkları ve Doğumen_US
dc.titleSpectroscopy analysis of uterine leiomyomas before and after treatment with GnRH-aen_US
dc.typeArticleen_US

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