The effects of Gingko biloba extract on acetic acid-induced colitis in rats

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dc.authorscopusid55396465200
dc.authorscopusid12544770600
dc.authorscopusid13205562700
dc.authorscopusid23018615700
dc.authorscopusid6602609706
dc.authorscopusid14719302100
dc.authorscopusid8587623600
dc.contributor.authorHarputluo?lu M.M.M.
dc.contributor.authorDemirel U.
dc.contributor.authorYücel N.
dc.contributor.authorKarada? N.
dc.contributor.authorTemel I.
dc.contributor.authorFirat S.
dc.contributor.authorAra C.
dc.date.accessioned2024-08-04T20:01:02Z
dc.date.available2024-08-04T20:01:02Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aims: Gingko biloba is an antioxidant substance which has antagonistic activity on platelet-activating factor. We aimed to investigate the antioxidant effect and the histopathologic changes caused by Gingko biloba on acetic acid-induced colitis. Methods: Totally 22 rats were divided into three groups. Group 1 (n=7) served as the control group. Group 2 (n=7) and Group 3 (n=8) were given 2 ml/day of 4% acetic acid by intracolonic instillation for three days. Gingko biloba (100 mg/kg) was then given only to Group 3 intraperitoneally for three days. Oxidative stress was assessed by determinate tissue and serum malondialdehyde (MDA) levels, and colonic damage was assessed by histologic examination. Results: Depth of necrosis, extent of necrosis, degree of inflammation, extent of inflammation, fibrosis and total histologic scores in Group 2 were significantly higher than in the control group (p<0.05). The same parameters were lower in Group 3 versus Group 2, but the difference was not significant. Tissue and serum MDA levels in Group 2 were significantly higher than Group 1 (p<0.01 and 0.05, respectively). Again, the same parameters in Group 3 were lower than in Group 2, but the difference was not significant statistically. Conclusions: Gingko biloba did not significantly affect histopathological and oxidative stress parameters in experimental colitis.en_US
dc.identifier.endpage182en_US
dc.identifier.issn1300-4948
dc.identifier.issue3en_US
dc.identifier.pmid16941250en_US
dc.identifier.scopus2-s2.0-34147152265en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://hdl.handle.net/11616/91208
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetic aciden_US
dc.subjectColitisen_US
dc.subjectGingko bilobaen_US
dc.subjectMalondialdehydeen_US
dc.subjectOxidative stressen_US
dc.titleThe effects of Gingko biloba extract on acetic acid-induced colitis in ratsen_US
dc.typeArticleen_US

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