Quercetin dose affects the fate of hepatic ischemia and reperfusion injury in rats: An experimental research

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dc.authoridSahinturk, Varol/0000-0003-2317-3644
dc.authoridAlatas, Ozkan/0000-0002-1753-8873
dc.authoridUylas, Ufuk/0000-0003-4195-5498
dc.authorwosidSahinturk, Varol/V-5195-2017
dc.authorwosidAlatas, Ozkan/ABH-4907-2020
dc.authorwosidUylas, Ufuk/A-1827-2019
dc.contributor.authorUylas, Mustafa Ufuk
dc.contributor.authorSahin, Adnan
dc.contributor.authorSahinturk, Varol
dc.contributor.authorAlatas, Ibrahim Ozkan
dc.date.accessioned2024-08-04T20:44:24Z
dc.date.available2024-08-04T20:44:24Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Quercetin found in fruits and vegetables has an antioxidative effect. We aimed to investigate the protective effects of quercetin according to different doses on hepatic and ischemia-reperfusion (I/R) injury. METHODS: Fifty mature male Sprague-Dawley rats were randomly divided into five groups (n = 10 for each). All the animal groups underwent laparotomy. Group 1 rats served as a sham-operated group. Groups 2-5 underwent 1 h hepatic ischemia and were followed by 2 h reperfusion. Group 3-5 animals received an additional intraperitoneal dose of 25, 50 or 100 mg/kg quercetin respectively before I/R operation. Blood samples were collected for determining serum aspartate transaminase (AST), alanine transaminase (ALT) and malondialdehyde (MDA) levels. Also, liver tissue samples were taken for measuring of liver MDA concentration and for histopathology assessment. RESULTS: The highest levels of biochemical parameters were observed in group 2. In quercetin-treated groups, serum AST, ALT, MDA levels, and tissue MDA concentration were decreased as inversely with increasing quercetin dose. Microscopic evaluation revealed that most conspicuous histological improvement was observed in 50 mg/kg quercetin co-treated rats. 25 and 100 mg/kg quercetin co-treatment could not protect completely against hepatic I/R injury. CONCLUSION: Quercetin can be effective in preventing of hepatic I/R injury when the correct dose was used.en_US
dc.identifier.doi10.1016/j.ijsu.2018.03.043
dc.identifier.endpage121en_US
dc.identifier.issn1743-9191
dc.identifier.issn1743-9159
dc.identifier.pmid29578092en_US
dc.identifier.scopus2-s2.0-85044472421en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijsu.2018.03.043
dc.identifier.urihttps://hdl.handle.net/11616/98212
dc.identifier.volume53en_US
dc.identifier.wosWOS:000432654400019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemiaen_US
dc.subjectReperfusionen_US
dc.subjectQuercetinen_US
dc.subjectLiveren_US
dc.titleQuercetin dose affects the fate of hepatic ischemia and reperfusion injury in rats: An experimental researchen_US
dc.typeArticleen_US

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