Synthesis and evaluation of novel N, N'-disubstituted benzimidazolium bromides salts as antitumor agents

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dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486;
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidmumcu, akın/ABG-9283-2020
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.contributor.authorKucukbay, Hasan
dc.contributor.authorMumcu, Akin
dc.contributor.authorTekin, Suat
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:41:51Z
dc.date.available2024-08-04T20:41:51Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNovel benzimidazolium bromides salts having (4-methoxyphenyl)ethyl, (phthalimide-2-yl)methyl, 4-nitrobenzyl, 2-phenylethyl, penthyl, or allyl groups were synthesized and their characterizations were conducted by H-1 and C-13 NMR and IR spectroscopic methods, and microanalysis. In vitro antitumor activities of the novel benzimidazole compounds (1-7) were determined by using ovarian (A2780) and prostate (PC-3) cancer cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MIT) assay. A time-dependent cell viability assay for the tested benzimidazole compounds was performed and the IC50 values of the compounds were calculated after treatment for 24 and 48 h. Our results indicate that the tested benzimidazole compounds show antitumor activity against A2780 and PC-3 cell lines (P < 0.05).en_US
dc.description.sponsorshipInonu University Research Fund [BAPB-2011/137]en_US
dc.description.sponsorshipWe wish to thank Inonu University Research Fund (BAPB-2011/137) for its financial support.en_US
dc.identifier.doi10.3906/kim-1510-15
dc.identifier.endpage+en_US
dc.identifier.issn1300-0527
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84975801275en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://doi.org/10.3906/kim-1510-15
dc.identifier.urihttps://hdl.handle.net/11616/97385
dc.identifier.volume40en_US
dc.identifier.wosWOS:000376305300003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBenzimidazole derivativesen_US
dc.subjectantitumor activityen_US
dc.subjectA2780en_US
dc.subjectPC-3en_US
dc.titleSynthesis and evaluation of novel N, N'-disubstituted benzimidazolium bromides salts as antitumor agentsen_US
dc.typeArticleen_US

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