New silver N-heterocyclic carbenes complexes: Synthesis, molecular docking study and biological activities evaluation as cholinesterase inhibitors and antimicrobials

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dc.authoridDundar, Muhammed/0000-0001-6509-2012
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridKarci, Huseyin/0000-0002-5709-1623
dc.authoridMOKRANI, El Hassen/0000-0002-2725-2940
dc.authoridbensouici, chawki/0000-0003-4612-4642
dc.authorwosidDundar, Muhammed/AAN-1831-2020
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidKarci, Huseyin/AAC-3985-2022
dc.authorwosidbensouici, chawki/H-3088-2018
dc.contributor.authorLasmari, Sarra
dc.contributor.authorIkhlef, Sofiane
dc.contributor.authorBoulcina, Raouf
dc.contributor.authorMokrani, El Hassen
dc.contributor.authorBensouici, Chawki
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorDundar, Muhmammed
dc.date.accessioned2024-08-04T20:49:30Z
dc.date.available2024-08-04T20:49:30Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe focused our study for the conception and the synthesis of a new series of Silver (I) N-heterocyclic carbene complexes which were obtained from the corresponding N-heterocyclic carbene (NHC) precursors and their unsymmetrical benzimidazolium salts. These new Ag-NHC complexes were screened for their antibacterial, antifungal, and anti-cholinesterase activities. The biological activities of synthesized products were compared with standard drugs. N-heterocyclic carbenes 2a-f and complexes 3a-f exhibited moderate antibacterial and antifungal activities. The results proved that the compounds indicated moderate to excellent activity against both AChE and BuChE. It was found that most of the complexes displayed good AChE and BuChE inhibitory activities. In particular, compounds 3c and 3e were the most potent inhibitors in the series with IC50 values of 8.56 +/- 1.17 mu M and 5.05 +/- 0.30 mu M against AChE and BChE, respectively. Docking studies revealed that compounds 3c and 3e bind manly to the catalytic anionic site (CAS) of the AChE, and BChE respectively. (C) 2021 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTechnological and Scientific Research Council of Turkey TUBITAK [117R010]; Ministere de l'Enseignement Superieur et de la Recherche Scientifique (Algeria); la Direction de la Cooperation et des Echanges Interuniversitairesen_US
dc.description.sponsorshipThis work was supported by the Technological and Scientific Research Council of Turkey TUBITAK (Project No: 117R010). The authors acknowledge le Ministere de l'Enseignement Superieur et de la Recherche Scientifique (Algeria), and la Direction de la Cooperation et des Echanges Interuniversitaires for financial support of Programme National Exceptionnel (PNE) program, and dedicate this work to the bright memory of their wonderful colleague, Professor Dahmane Tebbani, who recently passed away.en_US
dc.identifier.doi10.1016/j.molstruc.2021.130399
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85104588480en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2021.130399
dc.identifier.urihttps://hdl.handle.net/11616/99894
dc.identifier.volume1238en_US
dc.identifier.wosWOS:000663305200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazolium saltsen_US
dc.subjectN-heterocyclic carbenesen_US
dc.subjectAg(i)-nhc complexesen_US
dc.subjectAntimicrobialsen_US
dc.subjectCholinesterase inhibitorsen_US
dc.subjectMolecular dockingen_US
dc.titleNew silver N-heterocyclic carbenes complexes: Synthesis, molecular docking study and biological activities evaluation as cholinesterase inhibitors and antimicrobialsen_US
dc.typeArticleen_US

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