(E)-1-(4-Hydroxyphenyl)-3-(substituted-phenyl) prop-2-en-1-ones: Synthesis, in Vitro Cytotoxic Activity and Molecular Docking Studies

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dc.authorscopusid57217078673
dc.authorscopusid58702623700
dc.authorscopusid57523753400
dc.authorscopusid57197682313
dc.authorscopusid55775592400
dc.authorscopusid56779753300
dc.authorscopusid55256779100
dc.contributor.authorSirka L.
dc.contributor.authorDoğan H.
dc.contributor.authorBahar M.R.
dc.contributor.authorÇalışkan E.
dc.contributor.authorTekin S.
dc.contributor.authorUslu H.
dc.contributor.authorKoran K.
dc.date.accessioned2024-08-04T20:02:19Z
dc.date.available2024-08-04T20:02:19Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of chalcone compounds (2–11) were designed and synthesized to determine their cytotoxic effects. The structures of 2–11 were fully characterized by their physical and spectral data. The in vitro cytotoxic effects of 2–11 were evaluated against human ovarian cancer (A2780), breast cancer (MCF-7) and prostate cancer (PC-3 and LNCaP) cell lines. The activity potentials of compounds were further evaluated through molecular docking studies with AutoDock4 and Vina softwares. All the compounds (except compound 5) showed significant cytotoxic effects at high doses in all cancer cell lines. Among all the compounds studied, one compound i.e. compound 2 demonstrated dose-dependent activity, particularly against A2780/LNCaP cancer cell lines. The most effective compounds 8, 9, 10 and 11 reduced the cell viability of A2780, MCF-7, PC-3 and LNCaP cells by 50–98%, while other compounds 2, 4 and 7 reduced the cell viability of A2780 cells by 70–90% at concentrations of 50 and 100 µM. © 2022 Slovensko Kemijsko Drustvo. All rights reserved.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 116Z758en_US
dc.description.sponsorshipThe researchers are grateful to The Scientific and Technological Research Council of Turkey for financial support of this work (Project no: 116Z758).en_US
dc.identifier.doi10.17344/acsi.2022.7080
dc.identifier.endpage292en_US
dc.identifier.issn1318-0207
dc.identifier.issue2en_US
dc.identifier.pmid35861092en_US
dc.identifier.scopus2-s2.0-85134779767en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage281en_US
dc.identifier.urihttps://doi.org/10.17344/acsi.2022.7080
dc.identifier.urihttps://hdl.handle.net/11616/91603
dc.identifier.volume69en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSlovensko Kemijsko Drustvoen_US
dc.relation.ispartofActa Chimica Slovenicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectA2780en_US
dc.subjectChalconeen_US
dc.subjectcytotoxicen_US
dc.subjectmolecular dockingen_US
dc.subjectMTT assayen_US
dc.title(E)-1-(4-Hydroxyphenyl)-3-(substituted-phenyl) prop-2-en-1-ones: Synthesis, in Vitro Cytotoxic Activity and Molecular Docking Studiesen_US
dc.typeArticleen_US

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