Expression of Matrix Metalloproteinases 2 and 9 in Donor Liver, Cirrhotic Liver, and Acute Rejection After Human Liver Transplantation

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.contributor.authorKirimlioglu, H.
dc.contributor.authorKirimlioglu, V.
dc.contributor.authorYilmaz, S.
dc.date.accessioned2024-08-04T20:31:06Z
dc.date.available2024-08-04T20:31:06Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMatrix proteinases are known to play an important role in the cell migration during cancer invasion, in organ development, and in tissue damage during inflammatory process. Among the matrix proteinases, matrix metalloproteinases (MMP) are the most powerful proteinases. Changes at the extracellular matrix components play an essential role in acute rejection after orthotopic liver transplantation (OLT). This prospective clinical study investigated the alterations in the expression of MMP-2 (72-kd gelatinase type IV collagenase [gelatinase A]) and MMP-9 (92-kd gelatinase type IV collagenase [gelatinase B]) in patients with acute cellular rejection (ACR) compared with the biopsies of cirrhotic livers (CL) of patients who underwent OLT, and with healthy livers (HL) of the donors. Although MMP-2 expression was not present in the hepatocytes of the HL, it was in the endothelium; it was moderate in CL and severe in the livers suffering from ACR. MMP-9 expression, on the other hand, is found to be present only in the inflammatory cells, with an increasing intensity in HL, CL, and in livers suffering from ACR. The results suggest that MMP-2 and MMP-9, beside their roles in liver injury with tissue remodeling and fibrosis as mentioned in the previous studies, can be a marker of acute rejection.en_US
dc.identifier.doi10.1016/j.transproceed.2008.09.033
dc.identifier.endpage3577en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue10en_US
dc.identifier.pmid19100442en_US
dc.identifier.scopus2-s2.0-57549096359en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3574en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2008.09.033
dc.identifier.urihttps://hdl.handle.net/11616/94712
dc.identifier.volume40en_US
dc.identifier.wosWOS:000262133300070en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInhibitorsen_US
dc.subjectFibrosisen_US
dc.subjectMatrix-Metalloproteinase-9en_US
dc.subjectMechanismen_US
dc.subjectTumorsen_US
dc.subjectMmp-9en_US
dc.subjectMiceen_US
dc.subjectRaten_US
dc.titleExpression of Matrix Metalloproteinases 2 and 9 in Donor Liver, Cirrhotic Liver, and Acute Rejection After Human Liver Transplantationen_US
dc.typeArticleen_US

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