Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation

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dc.contributor.authorYıldız, Azibe
dc.contributor.authorCiftci, Tuba
dc.contributor.authorPolat, Seyhan
dc.contributor.authorGunata, Mehmet
dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorTemelli, Öztun
dc.contributor.authorPolat, Alaadin
dc.date.accessioned2024-08-04T19:51:23Z
dc.date.available2024-08-04T19:51:23Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Damage in the central nervous system caused by cranial radiotherapy (RT) has been linked to neuroinflammation due to microglial activation. Evidence reveals that resveratrol (RES) exerts neuroprotective effects by inhibiting neuroinflammation. There are limited studies investigating the effects of RES on microglia-related neuroinflammation developed as a result of RT. Therefore, this study was designed to investigate the effects of RES on RT-induced microglial- related neuroinflammation. Materials and Methods: Rats were simple randomly divided into three groups. Sham (SH) group received ethanol solution on the 1st-14th days of the study. RT group was applied a single dose of total cranial 15 Gy X radiation on the 7th day of the study. RES group was administered a dose of 20 mg/kg on the 1st-14th days of the study and a single dose of total cranial 15 Gy X radiation on the 7th day of the study. The brain tissues removed at the end of the experiment were subjected to histological techniques and procedures for histological and immunohistochemical examinations. The data were evaluated statistically. Results: RT administration caused histological changes such as neuron degeneration and edema in the brain tissue. In addition, RT administration induced a significant increase in CD68 and tumor necrosis factor-alpha (TNF-?) immunoreactivity. In the RES+RT group, it was observed that histological changes were alleviated, and CD68 and TNF-? immunoreactivities were decreased. In addition, a significant increase in the immunoreactivity of autophagy-related proteins was detected in this group. Conclusion: Evaluating together all the data, it was revealed that RES attenuates microglia- mediated neuroinflammation and neuronal degeneration.en_US
dc.identifier.endpage84en_US
dc.identifier.issn1308-9315
dc.identifier.issn2148-8797
dc.identifier.issue3en_US
dc.identifier.startpage79en_US
dc.identifier.trdizinid1173560en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1173560
dc.identifier.urihttps://hdl.handle.net/11616/88948
dc.identifier.volume36en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofFırat Üniversitesi Sağlık Bilimleri Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAnti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammationen_US
dc.typeArticleen_US

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