Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia

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dc.authoridBolay, Hayrunnisa/0000-0002-3357-7733
dc.authoridKilic, Ertugrul/0000-0001-6494-8923
dc.authoridGursoy-Ozdemir, Yasemin/0000-0002-0860-8964
dc.authoridDalkara, Turgay/0000-0003-3943-7819
dc.authorwosidBolay, Hayrunnisa/ABG-8829-2020
dc.authorwosidKilic, Ertugrul/W-4563-2018
dc.authorwosidKelestimur, Haluk/V-9392-2018
dc.authorwosidGursoy-Ozdemir, Yasemin/X-2778-2019
dc.contributor.authorKilic, E
dc.contributor.authorGursoy-Özdemir, Y
dc.contributor.authorBolay, H
dc.contributor.authorKelestimur, H
dc.contributor.authorDalkara, T
dc.date.accessioned2024-08-04T20:12:07Z
dc.date.available2024-08-04T20:12:07Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLarge infarcts develop in pinealectomized rats subjected to middle cerebral artery occlusion, which was attributed to loss of antioxidant action of melatonin. However, melatonin also has vascular actions, and pinealectomy may induce hypertension. The authors investigated (1) whether hemodynamic factors contribute to infarct development in pinealectomized rats, (2) whether melatonin administration can reverse the unfavorable effect of pinealectomy on infarct formation, and (3) whether melatonin can reduce the infarct volume in nonpinealectomized rats subjected to focal transient ischemia (2 hours middle cerebral artery occlusion, 22 hours reperfusion). Rats were pinealectomized 3 months before ischemia to eliminate any possible action of pinealectomy-induced hypertension on stroke. Blood pressure and regional CBF values during ischemia and reperfusion were not significantly different between pinealectomized and sham-operated rats, suggesting that pinealectomy-induced increase in infarct was not related to hemodynamic factors. The infarct volume resumed to the level of sham-operated rats on melatonin administration. Injection of melatonin (4 mg/kg) before both ischemia and reperfusion reduced infarct volume by 40% and significantly improved neurologic deficit scores in pinealectomized as well as sham-operated rats subjected to middle cerebral artery occlusion. These data suggest that physiologic melatonin release as well as exogenously given melatonin has a neuroprotective action in focal cerebral ischemia.en_US
dc.identifier.doi10.1097/00004647-199905000-00005
dc.identifier.endpage516en_US
dc.identifier.issn0271-678X
dc.identifier.issn1559-7016
dc.identifier.issue5en_US
dc.identifier.pmid10326718en_US
dc.identifier.scopus2-s2.0-0033509001en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage511en_US
dc.identifier.urihttps://doi.org/10.1097/00004647-199905000-00005
dc.identifier.urihttps://hdl.handle.net/11616/93202
dc.identifier.volume19en_US
dc.identifier.wosWOS:000084948600005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal of Cerebral Blood Flow and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.subjectcerebral ischemiaen_US
dc.subjectneuroprotectionen_US
dc.subjectcerebral blood flowen_US
dc.subjectantioxidantsen_US
dc.titlePinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemiaen_US
dc.typeArticleen_US

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