Rhamnolipids in Advanced Biomaterial Engineering: Applications in antimicrobial, wound healing, and drug delivery

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dc.contributor.authorColak, Aylin
dc.contributor.authorDik, Gamze
dc.contributor.authorUlu, Ahmet
dc.contributor.authorKahraman, Huseyin
dc.contributor.authorAtes, Burhan
dc.date.accessioned2026-04-04T13:35:00Z
dc.date.available2026-04-04T13:35:00Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBiosurfactants, widely utilized today in applications ranging from the food industry to medical fields, are among the most captivating biotechnological molecules for researchers. These remarkable molecules can be defined as amphiphilic compounds produced either on microbial cell surfaces or secreted extracellularly, comprising both hydrophobic and hydrophilic components. Among biosurfactants, rhamnolipids are the most extensively studied and widely used. Although rhamnolipids can be obtained and produced from different sources, they are predominantly obtained from Pseudomonas aeruginosa, whose structures are well-characterized. Rhamnolipids are important for their use in the medical field due to their many advantages such as being extremely biocompatible, exhibiting antibacterial properties, high selectivity, and stability. Specifically, synthesizing biomaterials for medical purposes using rhamnolipids or their functionalization with rhamnolipids can impart superior properties to these materials. Considering that these biomaterials will be used in clinical applications, they must exhibit antibacterial/antimicrobial properties. Furthermore, these biomaterials are highly suitable for applications such as drug delivery or wound healing. This review focuses on the preparation of rhamnolipids and applications of rhamnolipid-based biomaterials such as antimicrobial, wound healing, and drug delivery. It aims to highlight the significant potential of these materials in advancing the field of biomaterials science.
dc.identifier.doi10.1016/j.jddst.2025.107034
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.orcid0000-0001-5381-2780
dc.identifier.orcid0000-0002-4447-6233
dc.identifier.orcid0000-0001-6235-5497
dc.identifier.scopus2-s2.0-105005254988
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2025.107034
dc.identifier.urihttps://hdl.handle.net/11616/109547
dc.identifier.volume110
dc.identifier.wosWOS:001499274200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectRhamnolipids
dc.subjectBiosurfactants
dc.subjectBiomaterials
dc.subjectBiomedical applications
dc.subjectPurification methods
dc.titleRhamnolipids in Advanced Biomaterial Engineering: Applications in antimicrobial, wound healing, and drug delivery
dc.typeReview

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