Effect of steroid on mitochondrial oxidative stress enzymes, intestinal microflora, and bacterial translocation in rats subjected to temporary liver inflow occlusion

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidPiskin, Turgut/HKV-8614-2023
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.contributor.authorKirimlioglu, V
dc.contributor.authorKirimlioglu, H
dc.contributor.authorYilmaz, S
dc.contributor.authorPiskin, T
dc.contributor.authorTekerekoglu, S
dc.contributor.authorBayindir, Y
dc.date.accessioned2024-08-04T20:15:21Z
dc.date.available2024-08-04T20:15:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description8th Meeting of the Turkish-Transplantation-Society -- JUN 22-24, 2005 -- Ankara, TURKEYen_US
dc.description.abstractProtective effects of steroids against ischemia-reperfusion (I/R) injury are well known, but there is little information about the influence of temporary inflow occlusion on intestinal barrier function or bacterial translocation. The aim of this experimental study was to investigate the effects on liver, kidney, spleen, Heal mitochondrial stress enzymes, and bacterial translocation of methylprednisolone (MP) in rats undergoing temporary liver inflow occlussion. Twenty-seven pathogen-free Wistar albino rats were randomized into three groups: group A: I/R (n = 10); group B: I/R + MP (n = 10); and group C: sham (n = 7). Rats in groups A and B were subjected to 20 minutes of portal vein and hepatic artery occlusion with 3 mg/kg MP injected into group B animals intraperitoneally during the occlusion. Twenty-two hours later, all rats were sacrificed to measure mitochondrial oxidative stress enzymes in liver, kidney, spleen, and ileum. We evaluated intestinal bacterial counts, intestinal mucosal histopathology, bacterial translocation to mesenteric lymph nodes (MLN), liver, spleen, and kidney. Decreased levels of malondialdehyde and increased levels of glutathione were observed in all examined tissues of group B compared to those of group A rats. Statistically significant increases in the intestinal counts of Klebsiella spp and Proteus spp and of bacterial translocation to liver, kidney, spleen, and MLN were measured in group B with respect to group A.en_US
dc.description.sponsorshipTurkish Transplantat Socen_US
dc.identifier.doi10.1016/j.transproceed.2006.01.018
dc.identifier.endpage381en_US
dc.identifier.issn0041-1345
dc.identifier.issue2en_US
dc.identifier.pmid16549125en_US
dc.identifier.scopus2-s2.0-33645051976en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage378en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2006.01.018
dc.identifier.urihttps://hdl.handle.net/11616/94317
dc.identifier.volume38en_US
dc.identifier.wosWOS:000236440100009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectCirrhotic-Patientsen_US
dc.subjectHepatic Resectionen_US
dc.subjectInjuryen_US
dc.subjectMechanismsen_US
dc.subjectMelatoninen_US
dc.titleEffect of steroid on mitochondrial oxidative stress enzymes, intestinal microflora, and bacterial translocation in rats subjected to temporary liver inflow occlusionen_US
dc.typeConference Objecten_US

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