Effect of Intranasal Estrogen on Vocal Quality

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dc.authoridKIZILAY, Ahmet/0000-0003-3048-6489
dc.authoridEngin-Ustun, Yaprak/0000-0002-1011-3848
dc.authorwosidKIZILAY, Ahmet/ABI-8293-2020
dc.authorwosidUstun, Yaprak/KFQ-9767-2024
dc.contributor.authorFirat, Yezdan
dc.contributor.authorEngin-Ustun, Yaprak
dc.contributor.authorKizilay, Ahmet
dc.contributor.authorUstun, Yusuf
dc.contributor.authorAkarcay, Mustafa
dc.contributor.authorSelimoglu, Erol
dc.contributor.authorKafkasli, Ayse
dc.date.accessioned2024-08-04T20:32:12Z
dc.date.available2024-08-04T20:32:12Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of this study was to evaluate the effect of intranasal estrogen therapy on female vocal quality. Thirty-two women who had surgically induced menopause were included into the study group and examined through hall year for this study. Estrogen treatment was proposed to all of the patients. Twenty-three of them accepted the treatment protocols including oral (n = 12) (2 mg estradiol; Estrofem; Novo Nordisk, Denmark) and intranasal (n = 11) (300 mcg 17beta-estradiol; Aerodiol; Servier, Chambray-les-Tours, France) form of estrogen. The rest of patients refused estrogen treatment and those patients constituted the control group (n = 9). Vocal changes were evaluated with Voice Handicap Index (VHI) and acoustic analysis of voice variations (fundamental frequency [F0], SD F0, jitter, shimmer, normalized voice energy, and harmonics-to-noise ratio) at baseline and after 1-year follow-up. According to VHI, while voice improvement was not clear in oral estrogen group, it was significant at intranasal estrogen group. Voice quality in patients treated with hormone replacement therapy (HRT) was significantly higher than patients without HRT. But between two treatment groups, there were no any statistical discrepancy. According to acoustic analysis, vocal stability among the women who use HRT was significantly better than those who did not use. Intranasal estrogen exerted the most significant effects on vocal stability. The data of our study support that voice undergoes changes in lack of estrogen in surgically induced menopausal women. Taken together with the relevant studies, while oral estrogen replacement therapy shows a favorable influence on voice quality, it seems to be more pronounced with intranasal estrogen than oral form.en_US
dc.identifier.doi10.1016/j.jvoice.2008.03.002
dc.identifier.endpage720en_US
dc.identifier.issn0892-1997
dc.identifier.issn1873-4588
dc.identifier.issue6en_US
dc.identifier.pmid18538987en_US
dc.identifier.scopus2-s2.0-70350575455en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage716en_US
dc.identifier.urihttps://doi.org/10.1016/j.jvoice.2008.03.002
dc.identifier.urihttps://hdl.handle.net/11616/94899
dc.identifier.volume23en_US
dc.identifier.wosWOS:000271777500011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofJournal of Voiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEstrogenen_US
dc.subjectHormone replacement therapyen_US
dc.subjectVoice qualityen_US
dc.subjectVoice analysisen_US
dc.titleEffect of Intranasal Estrogen on Vocal Qualityen_US
dc.typeArticleen_US

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