A molecularly imprinted whatman paper for clinical detection of propranolol

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dc.authoridZengin, Adem/0000-0002-6889-5387
dc.contributor.authorAkbulut, Yeliz
dc.contributor.authorZengin, Adem
dc.date.accessioned2024-08-04T20:46:53Z
dc.date.available2024-08-04T20:46:53Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDetermination of drug concentration in body fluids is important issue for clinical studies to arrange treatment of patients. In the present study, we concentrated on the preparation of propranolol-imprinted poly (N-acryloyl-L-phenylalanine) film on a paper surface for spectrophotometric detection of propranolol in human plasma samples. The surface characterization of the imprinted surface was carried out by attenuated total reflectancefourier transform spectroscopy, x-ray photoelectron spectroscopy, scanning electron microscopy and water contact angle measurements. Rebinding isotherms and kinetics were also investigated and maximum adsorption capacity of the imprinted paper surface was found to be 64.3 mg/g with high imprinting factor (4.20). Moreover, the results for selectivity and regeneration ability of the imprinted paper indicated that propranolol selectively interacted with the imprinted paper and had satisfactory reuse without changing its adsorption capacity. Under optimized conditions, the imprinted paper surface had a limit of detection of 0.3 mu g/mL with lower intraday and interday precisions for determination of propranolol. The proposed method was successfully applied to determine propranolol in plasma samples where it showed recoveries ranging from 97.0%-99.5%. The method was also compared with traditional ELISA method and the results showed that the proposed method is sensitive and selective. It is believed that the prepared paper-based molecularly imprinted polymers can be good alternatives to traditional drug assays in clinical practice.en_US
dc.description.sponsorshipScientific and Technical Council of Turkey (TUBITAK) [MAG-315M277]en_US
dc.description.sponsorshipThis work was financially supported by the Scientific and Technical Council of Turkey (TUBITAK), MAG-315M277. AZ also thanks Prof. Dr. Z. Suludere for SEM analysis.en_US
dc.identifier.doi10.1016/j.snb.2019.127276
dc.identifier.issn0925-4005
dc.identifier.scopus2-s2.0-85074016135en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.snb.2019.127276
dc.identifier.urihttps://hdl.handle.net/11616/98996
dc.identifier.volume304en_US
dc.identifier.wosWOS:000500702500010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofSensors and Actuators B-Chemicalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWhatman paperen_US
dc.subjectMolecularly imprinted polymersen_US
dc.subjectPropranololen_US
dc.subjectPlasma sampleen_US
dc.titleA molecularly imprinted whatman paper for clinical detection of propranololen_US
dc.typeArticleen_US

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