Effects of zoledronic acid on sutural bone formation: a computed tomography study

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dc.authorwosidBabacan, Hasan/AAI-3356-2020
dc.contributor.authorOzturk, Firat
dc.contributor.authorBabacan, Hasan
dc.contributor.authorGumus, Cesur
dc.date.accessioned2024-08-04T20:35:50Z
dc.date.available2024-08-04T20:35:50Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of systemically applied zoledronic acid (ZA) on osteoblastic bone formation and relapse in the rat sagittal suture after expansion. Eighteen 12-week-old male Wistar rats were divided into three groups. In groups 1 and 2, a saline solution was given subcutaneously after expansion and the retention period lasted for 14 and 7 days, respectively. In group 3, 0.1 mg of ZA was diluted with saline and given subcutaneously after expansion: the retention period lasted for 7 days. Computed tomography (CT) measurements were obtained at the start of the study (T1), after expansion (T2), after the retention period (T3), and after the follow-up period (T4). The amount of expansion and relapse and the density of the newly formed bone in the expansion area were measured. The mean bone density values in hounsfield unit (HU) of the newly formed bone were recorded using MX View Workstation. Data were analysed using the Kruskal-Wallis, Friedman, Wilcoxon, and Mann-Whitney U-tests. The results showed that there were significant differences between the groups in the density of newly formed bone after the retention period (P < 0.05). Statistically significant differences were observed when the relapse percentages were compared between the groups (P < 0.05). ZA stimulated bone formation and decreased the relapse ratio after expansion in the rat sagittal suture.en_US
dc.identifier.doi10.1093/ejo/cjq160
dc.identifier.endpage146en_US
dc.identifier.issn0141-5387
dc.identifier.issn1460-2210
dc.identifier.issue2en_US
dc.identifier.pmid21382907en_US
dc.identifier.scopus2-s2.0-84859363485en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.1093/ejo/cjq160
dc.identifier.urihttps://hdl.handle.net/11616/95608
dc.identifier.volume34en_US
dc.identifier.wosWOS:000302301300002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofEuropean Journal of Orthodonticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBisphosphonate-Associated Osteonecrosisen_US
dc.subjectDistraction Osteogenesisen_US
dc.subjectCancer-Chemotherapyen_US
dc.subjectMidpalatal Sutureen_US
dc.subjectTooth Movementsen_US
dc.subjectJawsen_US
dc.subjectResorptionen_US
dc.subjectExpansionen_US
dc.subjectRatsen_US
dc.subjectStimulationen_US
dc.titleEffects of zoledronic acid on sutural bone formation: a computed tomography studyen_US
dc.typeArticleen_US

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