The protective effect of fish oil against cisplatin induced eye damage in rats

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridGul, Burcu/0000-0002-9122-8953
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidGul, Burcu/V-9452-2018
dc.contributor.authorBaykalir, Burcu Gul
dc.contributor.authorCiftci, Osman
dc.contributor.authorCetin, Asli
dc.contributor.authorTurkmen, Nese Basak
dc.date.accessioned2024-08-04T20:43:58Z
dc.date.available2024-08-04T20:43:58Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOcular toxicity induced by anticancer chemotherapy is not uncommon, but underestimated and under-reported. Visual changes have been attributed to a number of chemotherapeutic agents in humans. Cisplatin (CP), a heavy metal compound, is used in the treatment of many types of tumours. CP is known to produce nonspecific blurred vision, papilledema, and optic neuritis for high doses as well as cumulative dose regimens. The aim of this study was to investigate the possible beneficial effects of fish oil (FO) on eye tissue oxidative status and histological alterations against CP-induced in the rats. The animals were randomly divided into the following four groups: the control, CP, FO, and CP+FO groups. CP was intraperitoneally administered at the dose of 7mg/kg and FO was orally given at 1 softgel per day for 14days. The eye injury was assessed by biochemical and histological examinations. The levels of thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were evaluated in the eye tissue. TBARS levels were significantly higher, the activities of the antioxidant enzyme and GSH levels were significantly lower in the CP group than in the control group. The histopathological evaluation also confirmed the foregoing findings. On the other hand, treatment of FO ameliorated the biochemical and histological alterations caused by CP. The results showed that treatment with FO may protect against the negative ocular effects of CP.en_US
dc.identifier.doi10.1080/15569527.2017.1361438
dc.identifier.endpage156en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue2en_US
dc.identifier.pmid28789573en_US
dc.identifier.scopus2-s2.0-85028538212en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2017.1361438
dc.identifier.urihttps://hdl.handle.net/11616/97953
dc.identifier.volume37en_US
dc.identifier.wosWOS:000429276400008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectfish oilen_US
dc.subjecteyeen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.titleThe protective effect of fish oil against cisplatin induced eye damage in ratsen_US
dc.typeArticleen_US

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