The effectiveness of olmesartan on inflammation at cardiopulmonary bypass
| dc.contributor.author | Ozguler, Ibrahim Murat | |
| dc.contributor.author | Ustunel, Latif | |
| dc.date.accessioned | 2022-03-15T08:07:18Z | |
| dc.date.available | 2022-03-15T08:07:18Z | |
| dc.date.issued | 2021 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: Systemic inflammatory response syndrome may develop after coronary artery bypass graft surgery that performed by cardiopulmonary bypass technique. It is known that olmesartan, an angiotensin II receptor blocker, has anti-inflammatory effects. The antiinflammatory efficacy of olmesartan treatment was investigated in patients undergoing cardiopulmonary bypass.Materials and Methods: The study included 50 patients (14 female, 36 male) between 30-80 years of age were underwent CABG surgery. Patients were randomly assigned to control (Group C) and olmesartan (Group O) gruoups. Group O were treated with a single dose of 10 mg per day; 5 days preoperatively and 35 days postoperatively, 30 mg at the operation day. Samples were taken before the induction of anesthesia (T1), 5 minutes before cross clamping (T2), 5 minutes after cross clamping (T3), after protamine infusion (T4), postoperative day 3 (T5) and postoperative day 35 (T6) for total serum levels of IL-6, IL-10 and IL-18; for h-CRP levels preoperative (T1) and postoperative day 35 (T2).Results: Statistically significant decrease of CRP levels were observed on the postoperative 35th day in Group O (p0.05). Statistically significant decrease of IL-6 levels were observed in the Group O after protamine infusion (T4) and postoperative 3rd day (T5) (p 0.05).There was a statistically significant increase at 5 min. after the cross declamping time (T3) for IL-10 levels (p0.05).Conclusion: Although the anti-inflammatory efficacy of olmesartan has been proven, it can be accomplished by combining it with drugs that have anti-inflammatory effects like statins or dose increasing. | en_US |
| dc.identifier.citation | Murat Ozguler, I., & Ustunel, L. (2021). The effectiveness of olmesartan on inflammation at cardiopulmonary bypass . Annals of Medical Research, | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/55569 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | The effectiveness of olmesartan on inflammation at cardiopulmonary bypass | en_US |
| dc.type | Article | en_US |
