Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and plasma concentrations of asymmetric dimethylarginine in Turkish pre-eclamptic women without fetal growth retardation

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dc.authoridIlhan, Nevin/0000-0002-0208-8929
dc.authoridİLHAN, NECİP/0000-0001-9997-0418;
dc.authorwosidIlhan, Nevin/J-5761-2017
dc.authorwosidİLHAN, NECİP/V-8908-2018
dc.authorwosidkaman, dilara/V-9024-2018
dc.contributor.authorTuran, Fahri
dc.contributor.authorIlhan, Necip
dc.contributor.authorKaman, Dilara
dc.contributor.authorAtes, Kadir
dc.contributor.authorKafkasli, Ayse
dc.date.accessioned2024-08-04T20:32:24Z
dc.date.available2024-08-04T20:32:24Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAims: Pre-eclampsia (PE) is a leading cause of maternal death worldwide, affecting 3 to 5% of all pregnancies. We analyzed the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and asymmetric dimethylarginine (ADMA) in 55 Turkish patients with PE without fetal growth retardation (FGR) and in 54 healthy pregnant women. Methods: Restriction fragment length polymorphism analysis of Glu298Asp of the endothelial nitric oxide synthase gene was evaluated by amplification of genomic DNA isolated from whole blood followed by digestion with the restriction enzyme Frio. PE was defined according to the Working Group2000 criteria as high blood pressure (>= 140/90 mmHg after 20 weeks of gestation) and proteinuria (> 300 mg/24 h). We excluded the women with FGR Serum arginine, with only ADMA and symmetric dimethylarginine (SDMA) levels measured by high-performance liquid chromatography. Results: Genotypes were defined as GG, GT and TT according to the presence of the G and T alleles. In this case-control study, we did not find any significant difference in either the genotypic distribution or allelic frequency of Glu298Asp gene polymorphism between the pre-eclamptic patients and healthy pregnant women. Serum ADMA, arginine and SDMA levels were higher in patients with PE compared with healthy pregnant women (respectively, P < 0.0001, P < 0.0001, P < 0.0001). Conclusions: The results suggested a lack of association between the Glu298Asp gene polymorphism and pre-eclampsia without FGR in the Turkish population. But elevated ADMA and SDMA levels suggest that ADMA has a role in the pathogenesis of PE.en_US
dc.identifier.doi10.1111/j.1447-0756.2010.01172.x
dc.identifier.endpage501en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue3en_US
dc.identifier.pmid20598027en_US
dc.identifier.scopus2-s2.0-77953335372en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage495en_US
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2010.01172.x
dc.identifier.urihttps://hdl.handle.net/11616/95056
dc.identifier.volume36en_US
dc.identifier.wosWOS:000278563400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADMAen_US
dc.subjecteNOS gene polymorphismen_US
dc.subjectpre-eclampsiaen_US
dc.titleGlu298Asp polymorphism of the endothelial nitric oxide synthase gene and plasma concentrations of asymmetric dimethylarginine in Turkish pre-eclamptic women without fetal growth retardationen_US
dc.typeArticleen_US

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