An observational, multicenter, registry-based cohort study of Turkish Neonatal Society in neonates with Hypoxic ischemic encephalopathy

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dc.authoridArman, Didem/0000-0002-7218-9207
dc.authoridAKIN, Mustafa Ali/0000-0001-6102-2703
dc.authoridAKCAN, ABDULLAH/0000-0003-0181-1166
dc.authoridAKYILDIZ, CAN/0000-0002-7087-7006
dc.authoridDeveci, Mehmet Fatih/0000-0002-3328-4156
dc.authoridMert, Mustafa Kurthan/0000-0002-2789-2710
dc.authoridUnal, Sezin/0000-0002-5124-4422
dc.authorwosidOrman, Ayşen/AAK-3647-2020
dc.authorwosidArman, Didem/HJH-2170-2023
dc.authorwosidAKIN, Mustafa Ali/L-3654-2013
dc.authorwosidAKCAN, ABDULLAH/Q-3855-2019
dc.authorwosidAKYILDIZ, CAN/ABP-7289-2022
dc.authorwosidDeveci, Mehmet Fatih/IYS-3534-2023
dc.authorwosidYaprak, Deniz/JMC-0307-2023
dc.contributor.authorOkulu, Emel
dc.contributor.authorHirfanoglu, Ibrahim Murat
dc.contributor.authorSatar, Mehmet
dc.contributor.authorErdeve, Omer
dc.contributor.authorKoc, Esin
dc.contributor.authorOzlu, Ferda
dc.contributor.authorGokce, Mahmut
dc.date.accessioned2024-08-04T20:54:56Z
dc.date.available2024-08-04T20:54:56Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Hypoxic ischemic encephalopathy (HIE) is a significant cause of mortality and short- and long-term morbidities. Therapeutic hypothermia (TH) has been shown to be the standard care for HIE of infants >= 36 weeks gestational age (GA), as it has been demonstrated to reduce the rates of mortality, and adverse neurodevelopmental outcomes. This study aims to determine the incidence of HIE in our country, to assess the TH management in infants with HIE, and present short-term outcomes of these infants. Methods The Turkish Hypoxic Ischemic Encephalopathy Online Registry database was established for this multicenter, prospective, observational, nationally-based cohort study to evaluate the data of infants born at >= 34 weeks GA who displayed evidence of neonatal encephalopathy (NE) between March, 2020 and April 2022. Results The incidence of HIE among infants born at >= 36 weeks GA (n = 965) was 2.13 per 1000 live births (517:242440), and accounting for 1.55% (965:62062) of all neonatal intensive care unit admissions. The rates of mild, moderate and severe HIE were 25.5% (n = 246), 58.9% (n = 568), and 15.6% (n = 151), respectively. Infants with severe HIE had higher rates of abnormal magnetic resonance imaging (MRI) findings, and mortality (p<0.001). No significant difference in mortality and abnormal MRI results was found according to the time of TH initiation (<3 h, 3-6 h and >6 h) (p>0.05). TH was administered to 85 (34.5%) infants with mild HIE, and of those born of 34-35 weeks of GA, 67.4% (n = 31) received TH. A total of 58 (6%) deaths were reported with a higher mortality rate in infants born at 34-35 weeks of GA (OR 3.941, 95% Cl 1.446-10.7422, p = 0.007). Conclusion The incidence of HIE remained similar over time with a reduction in mortality rate. The timing of TH initiation, whether <3 or 3-6 h, did not result in lower occurrences of brain lesions on MRI or mortality. An increasing number of infants with mild HIE and late preterm infants with HIE are receiving TH; however, the indications for TH require further clarification. Longer follow-up studies are necessary for this vulnerable population.en_US
dc.identifier.doi10.1371/journal.pone.0295759
dc.identifier.issn1932-6203
dc.identifier.issue12en_US
dc.identifier.pmid38096201en_US
dc.identifier.scopus2-s2.0-85179770987en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0295759
dc.identifier.urihttps://hdl.handle.net/11616/101727
dc.identifier.volume18en_US
dc.identifier.wosWOS:001158744900075en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWhole-Body Hypothermiaen_US
dc.subjectTherapeutic Hypothermiaen_US
dc.subjectTermen_US
dc.subjectNewbornsen_US
dc.subjectOutcomesen_US
dc.subjectInfantsen_US
dc.subjectDysfunctionen_US
dc.subjectSeverityen_US
dc.subjectInjuryen_US
dc.titleAn observational, multicenter, registry-based cohort study of Turkish Neonatal Society in neonates with Hypoxic ischemic encephalopathyen_US
dc.typeArticleen_US

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