Biochemical Studies to Understand Teratogenicity and Lethality Outcomes in Modified-FETAX

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dc.authorscopusid12760269900
dc.authorscopusid57203678980
dc.contributor.authorGüngördü A.
dc.contributor.authorTurhan D.O.
dc.date.accessioned2024-08-04T20:00:45Z
dc.date.available2024-08-04T20:00:45Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe frog embryo teratogenesis assay-Xenopus (FETAX) is a standardized test used to assess the toxic and teratogenic effects of xenobiotics. With this test, toxic and/or teratogenic concentrations of xenobiotic substances can be determined using morphological parameters such as lethality, length, and malformations in stage 8–11 Xenopus laevis embryos after 96 h exposure. These parameters enable the determination of the median lethal and effective concentrations (LC50 and EC50), minimum concentration to inhibit growth (MCIG), and teratogenic index of the tested chemical to reveal the short-term effects of relatively high concentrations. On the other hand, although FETAX provides quantitative and qualitative data on teratogenicity and toxicity, the biochemical and molecular mechanisms of these effects cannot be explained. Recent studies have tried to elucidate the mechanisms causing malformations and to explain the underlying causes of toxicity and teratogenicity by biochemical marker analysis. This chapter describes methods to analyze modified-FETAX and some detoxification and oxidative stress-related biomarkers during the early embryonic development of X. laevis. © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024.en_US
dc.identifier.doi10.1007/978-1-0716-3625-1_19
dc.identifier.endpage364en_US
dc.identifier.issn1064-3745
dc.identifier.pmid38285350en_US
dc.identifier.scopus2-s2.0-85183781011en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage351en_US
dc.identifier.urihttps://doi.org/10.1007/978-1-0716-3625-1_19
dc.identifier.urihttps://hdl.handle.net/11616/90979
dc.identifier.volume2753en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Inc.en_US
dc.relation.ispartofMethods in Molecular Biologyen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemical markersen_US
dc.subjectFETAXen_US
dc.subjectTeratogenicityen_US
dc.subjectToxicityen_US
dc.subjectXenopus laevisen_US
dc.titleBiochemical Studies to Understand Teratogenicity and Lethality Outcomes in Modified-FETAXen_US
dc.typeBook Chapteren_US

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