The effects of ghrelin on colonic anastomosis healing in rats

Basit Öğe Kaydı
dc.authorwosidceran ozcan, canan/HJZ-4187-2023
dc.authorwosidceran özcan, canan ceran/B-1867-2018
dc.contributor.authorCeran, Canan
dc.contributor.authorAksoy, Rauf Tugrul
dc.contributor.authorGulbahar, Ozlem
dc.contributor.authorOzturk, Figen
dc.date.accessioned2024-08-04T20:37:32Z
dc.date.available2024-08-04T20:37:32Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVES: In addition to its roles in the stimulation of growth hormone secretion and the regulation of appetite and metabolism, ghrelin exerts immunomodulatory, anti-inflammatory and antioxidant actions in several organ systems. In this study, we investigated the effects of ghrelin on the healing of experimental colonic anastomoses. METHODS: Wistar rats were randomly divided into two groups (n = 10 in each). A segment of colon was excised, and an end-to-end anastomosis was performed in the distal colon. The Ghrelin Group received 10 ng/kg/day IP ghrelin for seven days postoperatively, whereas the Control Group received an identical volume of saline. On the seventh postoperative day, the anastomotic bursting pressures and hydroxyproline levels were measured, and adhesion formation around the anastomoses was examined. Histopathological analyses were performed to evaluate inflammatory cell infiltration, fibroblast infiltration, collagen density and neovascularization. RESULTS: In the Ghrelin Group, the bursting pressure and hydroxyproline levels were significantly higher than in the Control Group. The adhesion formation scores were lower in the Ghrelin Group than in the Control Group. Although the inflammatory cell infiltration was diminished in the Ghrelin Group, the degrees of fibroblast infiltration, collagen density and neovascularization were not significantly different between the groups. CONCLUSION: Our results indicate that ghrelin improves the healing of colonic anastomoses in rats.en_US
dc.identifier.doi10.6061/clinics/2013(02)OA19
dc.identifier.endpage244en_US
dc.identifier.issn1807-5932
dc.identifier.issue2en_US
dc.identifier.pmid23525322en_US
dc.identifier.scopus2-s2.0-84875660465en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://doi.org/10.6061/clinics/2013(02)OA19
dc.identifier.urihttps://hdl.handle.net/11616/95998
dc.identifier.volume68en_US
dc.identifier.wosWOS:000316764000019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHospital Clinicas, Univ Sao Pauloen_US
dc.relation.ispartofClinicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGhrelinen_US
dc.subjectColonic Anastomosisen_US
dc.subjectAnastomosis Healingen_US
dc.titleThe effects of ghrelin on colonic anastomosis healing in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu